#pfs, .unresectable-efficacy #pfss {
  margin-top: 99px;
  padding-top: 13px;
}

.unresectable-efficacy .primary-navigation .nav.stacked-menu {
  display: none;ma
}

.unresectable-efficacy .primary-navigation .nav>li.list-2 a {
      /*font-weight: 800;*/
  color: #fff;
}

.unresectable-efficacy h1.margin-none {
  margin: 0;
}

.unresectable-efficacy #tagrisso-approvals {
  background: #F1F1F1;
  padding-top: 50px;
  padding-bottom: 90px;
}

.unresectable-efficacy #pfss {
  margin-top: 120px;
  padding-bottom: 30px;
}
  
  /*.unresectable-efficacy .banner-bg-section:after {*/
  /*    background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/inner-bg-v1.jpg) no-repeat;*/
  /*    padding: 0;*/
  /*    height: 100%;*/
  /*    background-size: 125% auto;*/
  /*    background-position: center;*/
  /*    display: block;*/
  /*    position: absolute;*/
  /*    content: "";*/
  /*    left: 0;*/
  /*    top: 0px;*/
  /*    width: 100%;*/
  /*    transition: 1s ease;*/
      /* background-size: 200% auto; */
  /*}*/
  
  /*  @keyframes scale-up {*/
  /*          from {*/
  /*            background-size: 125% auto;*/
  /*          }*/
  /*          to {*/
  /*            background-size: 200% auto;*/
  /*          }*/
  /*        }*/
  
  /*.dom-ready .banner-bg-section:after {*/
      /*background-size: 200% auto;*/
      /*background-position: center;*/
      /*background-position-x: center;*/
      /*transform: scale(1.5);*/
      
  /*    animation: 1.5s linear forwards scale-up;*/
  /*}*/
  
.unresectable-efficacy .container {
  width: 100%;
  padding: 0px;
}

.unresectable-efficacy .signi-stats-container,
  .unresectable-efficacy .targisso-intro-container .targisso-intro,
          .unresectable-efficacy .cns-event,
          .unresectable-efficacy .signi-stats-container,
          .unresectable-efficacy .pfs-container,
          .unresectable-efficacy .pfs-container .pfs-content .pfs-data,
          .unresectable-efficacy .data-maturity,
          .unresectable-efficacy .signi-stats-container-2,
          .unresectable-efficacy .bar-tag-plac,
          .unresectable-efficacy .startisifact-container,
          .unresectable-efficacy .tkt-container,
          .unresectable-efficacy .tkt-container .tkt-content > div > figure > img,
          .unresectable-efficacy .mdt-molecular-container,
          .unresectable-efficacy .tagrisso-laura-trail-cta,
          .unresectable-efficacy .egfrn-nslc p img {
  margin: 0 auto;
}

.pink-text {
  color: #FF00BA;
}

.unresectable-efficacy #subgroups {
  padding-top: 40px;
  padding-bottom: 32px;
}

.unresectable-efficacy #new-lesion-sites {
  padding-top: 55px;
  padding-bottom: 70px;
}

.unresectable-efficacy img.new-indication {
      /*position: relative;*/
      /*width: 222px;*/
      /*float: right;*/
      /*clear: both;*/
      /*margin-right: -93px;*/
      /*top: -60px;*/
      /*left: -19px;*/
  position: relative;
  width: 222px;
  float: right;
  clear: both;
  margin-right: -174px;
  top: -60px;
  left: -107px;
      /*transform: translate(130%);*/
  transform: translate(90%);
}

.unresectable-efficacy #pfss img.new-indication {
      /*width: 240px;*/
      /*left: -95px;*/
      /*width: auto;*/
      /*left: -8%;*/
      /*height: 138px;*/
      /*width: 300px;*/
      /*left: -5%;*/
  width: 240px;
  left: -8%;
  top: -31px;
}

img.new-indication.is-visible {
  transform: none;
  transition: all 1s ease-in-out;
  transition-delay: 0s;
}

.laura-nsclc .isiNode ul.isi-list ul {
  padding-left: 14px;
}

.unresectable-efficacy .targisso-intro-container {
  margin: 0px 0 5px;
}

.unresectable-efficacy .egfrn-nslc img.desktop-only {
  width: 100%;
}

.unresectable-efficacy .targisso-intro>h1 {
  margin-top: 15px;
  margin-bottom: 20px;
}

.unresectable-efficacy .subhead {
  margin-bottom: 20px;
  margin-top: 0px !important;
}

.unresectable-efficacy #new-lesion-sites .subhead {
  margin-top: -14px !important;
}
  /*.unresectable-efficacy .targisso-intro p,h1 {*/
  /*  margin-top:0px; */
  /*}*/
.unresectable-efficacy .targisso-intro-container .targisso-intro,
          .unresectable-efficacy .cns-event {
  max-width: 798px;
  margin-left: 0;
}
  
  /* updates */
  
.newlesions-graphics {
  margin: 40px 0 20px;
  display: none;
}
  
  
  /*graph*/
.cns-aura3-vertical-graph {
  position: relative;
  max-width: 600px;
  margin: 0 auto;
      /*left: 30px;*/
      /* margin-top: 45px; */
  margin-top: 80px;
      /* margin-bottom: -188px; */
  margin-bottom: -70px;
  margin-left: 250px;
}

hr.ver-line {
      /*height: 219px;*/
      /*width: 603px;*/
      /*width: 90%;*/
      /*margin-left: 0;*/
      /*margin-bottom: 21px;*/
  height: 347px;
      /* width: 603px; */
  width: 57%;
  margin-left: 0;
  margin-bottom: 21px;
  border-bottom: 2px solid #A0A0A0;
}

ul.scale {
  top: -1px;
}

.nobold {
  font-weight: 500;
}

li.ruler {
  width: 5px;
  height: 87px;
  border-top: 1px solid #9B9B9B;
}

p.purple-txt {
  font-size: 42px;
}

.cns-aura3-vertical-graph .small-text {
  position: relative;
  left: -6px;
}

.hor-txt1 {
  position: relative;
  top: -40px;
  font-size: 18px !important;
  left: 59px;
      /* max-width: 55px;*/
  ;
}

.hor-txt2 {
  position: relative;
  top: -70px;
  font-size: 18px !important;
  left: 209px;
  max-width: 100px;
}

.hor-txt3 {
  position: relative;
  font-size: 12px !important;
  top: -103px;
  left: 190px;
  max-width: 55px;
}

.hor-txt4 {
  position: relative;
  font-size: 12px !important;
  top: -134px;
  left: 260px;
  max-width: 55px;
}

.hor-txt5 {
  position: relative;
  font-size: 12px !important;
  top: -163px;
  left: 364px;
  max-width: 55px;
}

.hor-txt6 {
  position: relative;
  font-size: 12px !important;
  top: -194px;
  left: 436px;
  max-width: 55px;
}

.hor-txt7 {
  position: relative;
  font-size: 12px !important;
  top: -223px;
  left: 541px;
  max-width: 55px;
}

.hor-txt8 {
  position: relative;
  font-size: 12px !important;
  top: -253px;
  left: 613px;
  max-width: 55px;
}

.purple-txt span.small-text {
  font-size: 12px;
}

p.vertical-txt {
  position: absolute;
  top: -102px;
  bottom: 0;
  left: 69px;
  transform: rotate(270deg);
  font-size: 22px;
}

.top-txt {
  position: absolute;
  top: -58px;
  left: 24px;
}

.hor-txt2, .hor-txt1 {
  font-size: 18px;
  line-height: 23px;
}

.bar-one.bar-container {
      /*position: absolute;*/
      /*width: 55px;*/
      /*min-height: 0px;*/
      /*background: #5B305D;*/
      /*bottom: 275px;*/
      /*left: 15px;*/
      /*transition: 1s all ease;*/
  position: absolute;
  width: 105px;
  min-height: 0px;
  background: #5B305D;
  bottom: 95px;
  left: 46px;
  transition: 1s all ease;
}

.is-visible .bar-one {
      /*min-height: 47px;*/
  min-height: 110px;
}

.bar-grey-one.bar-container {
      /*position: absolute;*/
      /*width: 55px;*/
      /*min-height: 0px;*/
      /*background: #A0A0A0;*/
      /*bottom: 275px;*/
      /*left: 79px;*/
      /*transition: 1s all ease;*/
  position: absolute;
  width: 105px;
  min-height: 0px;
  background: #A0A0A0;
  bottom: 95px;
  left: 190px;
  transition: 1s all ease;
}

.bar-two.bar-container {
  position: absolute;
  width: 55px;
  min-height: 0px;
  background: #5B305D;
  bottom: 275px;
  left: 190px;
  transition: 1s all ease;
}

.bar-grey-two.bar-container {
  position: absolute;
  width: 55px;
  min-height: 0px;
  background: #A0A0A0;
  bottom: 275px;
  left: 255px;
  transition: 1s all ease;
}

.is-visible .bar-grey-one {
  min-height: 305px;
}
  
  /*.is-visible .bar-grey-one,*/
.is-visible .bar-grey-two,
  .is-visible .bar-grey-three {
  min-height: 160px;
}

.is-visible .bar-two {
  min-height: 35px;
}

.bar-three.bar-container {
  position: absolute;
  width: 55px;
  min-height: 0px;
  background: #5B305D;
  bottom: 275px;
  left: 364px;
  transition: 1s all ease;
}

.is-visible .bar-three {
  min-height: 18px;
}

.bar-grey-three.bar-container {
  position: absolute;
  width: 55px;
  min-height: 0px;
  background: #A0A0A0;
  bottom: 275px;
  left: 428px;
  transition: 1s all ease;
}

.is-visible .bar-grey-three {
  min-height: 60px;
}

.bar-four.bar-container {
  position: absolute;
  width: 55px;
  min-height: 0px;
  background: #5B305D;
  bottom: 275px;
  left: 540px;
  transition: 1s all ease;
}

.is-visible .bar-four {
  min-height: 7px;
}

.bar-grey-four.bar-container {
  position: absolute;
  width: 55px;
  min-height: 0px;
  background: #A0A0A0;
  bottom: 275px;
  left: 605px;
  transition: 1s all ease;
}

.is-visible .bar-grey-four {
  min-height: 60px;
}

.graph-indication-text {
  display: flex;
  gap: 100px;
  align-items: center;
  justify-content: center;
  margin-top: -41px;
  position: relative;
  top: -219px;
  left: -7px;
}

.graph-indication-text .text-purple {
  font-size: 16px;
  font-weight: 700;
  color: #5B305D;
  position: relative;
  left: -103px;
}

.graph-indication-text .text-grey {
  font-size: 14px;
  font-weight: 500;
  position: relative;
  left: 0px;
}

.graph-indication-text p:nth-child(2) {
  left: -65px;
}

.graph-indication-text p:nth-child(3) {
  left: -22px;
}

.big-grey-text {
  font-size: 42px;
  color: #606060;
  font-family: 'Barlow';
  font-weight: 700;
}
  
  /*.unresectable-efficacy .green-banner {*/
      /*transform: translateX(-47%);*/
      /*transform: translateX(-77%);*/
  /*    transform: translateX(-85%);*/
  /*}*/
  
  /*.unresectable-efficacy .green-banner.is-visible {*/
      /*transform: translateX(-77%);*/
  /*    transform: translateX(-77%);*/
  /*}*/
  
.unresectable-efficacy  .green-banner {
        /*transform: translateX(-47%);*/
        /*transform: translateX(-80%);*//*working*/
  transform: translateX(-82%);
}

.unresectable-efficacy .green-banner.is-visible {
  transition: 1s ease;
        /*transform: translateX(-84%);*/
  transform: translateX(-77%);
}
  
  /*graph*/
  
  
.unresectable-efficacy span.extrabold.hr-txt.purple-txt {
  font-size: 16px;
  line-height: 27px;
}

.unresectable-efficacy span.hr-txt.purple-txt {
  font-size: 16px;
  line-height: 22px;
  line-height: 19px;
}

.unresectable-efficacy .signi-stats-container .signi-stats .data-copy .copy-content .copy-content-sm.vs-txt {
  font-size: 16px !important;
  line-height: 19px !important;
}

.unresectable-efficacy .signi-stats-container .signi-stats .data-copy .copy-content {
  margin-bottom: 16px;
  margin-left: 10px !important;
  line-height: 19px !important;
}

.unresectable-efficacy .pfs-container .pfs-content p {
  color: #333;
}

.unresectable-efficacy p.footnotes.pill.new-pill {
  text-align: center;
}

#tagrisso-approvals {
    /*margin-top: 60px; */
  padding-bottom: 60px;
  z-index: 1;
}
  
  
  /*animation for indication table*/
      
.unresectable-efficacy .indication-block-desktop-animation {
  display: flex;
  justify-content: space-between;
  background: #F1F1F1;
  border: 1px solid #707070;
  border-radius: 10px;
  max-width: 820px;
      /*margin-top: 140px;*/
  margin-top: 122px;
  padding: 8px;
  position: relative;
      /* min-height: 300px; */
  max-height: 325px;
  margin-bottom: 77px;
}

.unresectable-efficacy #tagrisso-approvals.section-5 .indication-block-desktop-animation {
  margin-top: 121px;
}

.indication-block-desktop-animation a:nth-child(1),
  .indication-block-desktop-animation a:nth-child(3),
  .indication-block-desktop-animation a:nth-child(4) {
  position: relative;
     /*max-width: 180px;*/
  ;
}

.indication-block-desktop-animation a:nth-child(2) .unresectable-body-block {
  position: relative;
}

.indication-block-desktop-animation a:nth-child(2) .unresectable-sub-heading {
  padding-top: 87px;
}

.indication-block-desktop-animation a:nth-child(3) .locally-metastatic {
  position: relative;
}

.indication-block-desktop-animation a:nth-child(3) .locally-metastatic-heading-block {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/blue-arrow-shape.svg) no-repeat;
  background-size: 100%;
  min-height: 109px;
  margin-top: -49px;
  padding-top: 14px;
}

.indication-block-desktop-animation a:nth-child(3) .locally-metastatic-heading {
  display: block;
  align-items: center;
  justify-content: center;
  color: #5B305D;
  font-weight: bold;
  font-family: 'Barlow';
  border-top-left-radius: 6px;
  border-top-right-radius: 6px;
  font-size: 20px;
  line-height: 22px !important;
}

.indication-block-desktop-animation a:nth-child(4) .metastatic-heading-block {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/blue-arrow-shape.svg) no-repeat;
  background-size: 100%;
  min-height: 109px;
  margin-top: -49px;
  padding-top: 26px;
}

.indication-block-desktop-animation a:nth-child(4) .metastatic-sub-heading {
  color: #5B305D;
  font-size: 16px;
  font-weight: 800;
  font-family: 'Barlow', 'sans-serif';
  padding-bottom: 3px;
  border-bottom: 1px solid #5B305D;
  border-width: 1px;
  text-align: center;
  width: 101px;
  margin: 0 auto;
}

.indication-block-desktop-animation a:nth-child(2) {
  position: relative;
  max-width: 220px;
}

.resectable,
  .unresectable,
  .locally-metastatic,
  .metastatic {
  text-align: center;
      /*padding: 6px;*/
  width: 180px;
}
  
  /*.resectable-heading-block,*/
  /*.unresectable-heading-block,*/
  /*.locally-metastatic-heading-block,*/
  /*.metastatic-heading-block {*/
  /*    transform: translateY(-85px);*/
  /*    transition: 1s ease-in-out;*/
  /*}*/
  
  /*.is-visible .resectable-heading-block,*/
  /*.is-visible .unresectable-heading-block,*/
  /*.is-visible .locally-metastatic-heading-block,*/
  /*.is-visible .metastatic-heading-block {*/
  /*    transform: none;*/
  /*}*/
  
.resectable-heading-block {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/green-arrow-shape.svg) no-repeat;
  background-size: 100%;
  min-height: 110px;
  margin-top: -49px;
  padding-top: 25px;
}

.resectable-heading {
  display: block;
  align-items: center;
  justify-content: center;
  color: #5B305D;
  font-weight: bold;
  font-family: 'Barlow';
  border-top-left-radius: 6px;
  border-top-right-radius: 6px;
  font-size: 20px;
  line-height: 22px !important;
}

.resectable-sub-heading {
  color: #5B305D;
  font-size: 16px;
  font-weight: 800;
  font-family: 'Barlow', 'sans-serif';
  padding-bottom: 3px;
  border-bottom: 1px solid #5B305D;
  border-width: 1px;
  text-align: center;
  width: 101px;
  margin: 0 auto;
}

.resectable-indication-text {
  font-size: 14px;
  font-family: 'Barlow', 'sans-serif';
  color: #333333;
  padding: 6px;
  line-height: 16px !important;
}

.unresectable {
  background: #5B305D;
  position: relative;
      /*top: -55px;*/
  top: -80px;
  border-radius: 10px;
  min-width: 220px;
  padding-bottom: 6px;
}

.unresectable-heading-block {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/green-arrow-shape-solid.svg) no-repeat;
  background-size: 100%;
  min-height: 128px;
  position: absolute;
  min-width: 190px;
  top: -40px;
  margin: 0 auto;
  padding-top: 8px;
  padding-left: 6px;
  left: 14px;
}

.unresectable-heading {
  display: block;
  align-items: center;
  justify-content: center;
  color: #5B305D;
  font-weight: bold;
  font-family: 'Barlow';
  border-top-left-radius: 6px;
  border-top-right-radius: 6px;
  font-size: 20px;
  line-height: 20px !important;
}

.unresectable-sub-heading {
  color: #fff;
  font-size: 24px;
  font-weight: 800;
  font-family: 'Barlow', 'sans-serif';
  padding-bottom: 11px;
  border-width: 3px;
  text-align: center;
  width: 130px;
  margin: 0 auto;
  width: 100px;
  margin-top: 23px;
  padding-bottom: 8px;
  border-bottom: 1px solid #9c879d;
}

.unresectable-indication-text {
  font-size: 15px;
  line-height: 19px !important;
  letter-spacing: -0.3px;
  font-weight: 400;
  padding-left: 14px;
  padding-right: 14px;
      /*margin-top: 28px;*/
  margin-top: 16px;
  color: #FFFFFF;
  font-family: 'Barlow', 'sans-serif';
}

.fw-bold {
  font-weight: 700;
}
  
  /*.locally-metastatic {*/
  /*    min-width: 200px;*/
  /*}*/
  
.locally-metastatic-heading-block {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/blue-arrow-shape.svg) no-repeat;
  background-size: 100%;
  min-height: 100px;
  margin-top: -49px;
  padding-top: 14px;
}

.locally-metastatic-heading {
  display: block;
  align-items: center;
  justify-content: center;
  color: #5B305D;
  font-weight: bold;
  font-family: 'Barlow';
  border-top-left-radius: 6px;
  border-top-right-radius: 6px;
  font-size: 20px;
  line-height: 22px !important;
}

.locally-metastatic-sub-heading {
  color: #5B305D;
  font-size: 16px;
  font-weight: 800;
  font-family: 'Barlow', 'sans-serif';
  padding-bottom: 3px;
  border-bottom: 1px solid #5B305D;
  border-width: 1px;
  text-align: center;
  width: 101px;
  margin: 0 auto;
}

.locally-metastatic-indication-text {
  font-size: 14px;
  line-height: 16px !important;
  letter-spacing: -0.28px;
      /*padding-right: 25px;*/
  margin-top: 5px;
}

.locally-metastatic-body-block .footnote {
  font-size: 11px;
  line-height: 12px !important;
  letter-spacing: -0.11px;
  width: 95%;
      /*padding-left: 18px;*/
      /*margin-top: -13px;*/
  font-family: 'Barlow';
  font-weight: 100;
  margin-left: 6px;
}

#tagrisso-approvals.section-5 .locally-metastatic .locally-metastatic-body-block .footnote {
  margin-left: 6px;
}

.metastatic-heading-block {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/blue-arrow-shape.svg) no-repeat;
  background-size: 100%;
  min-height: 100px;
  margin-top: -49px;
  padding-top: 24px;
}

.metastatic-heading {
  display: block;
  align-items: center;
  justify-content: center;
  color: #5B305D;
  font-weight: bold;
  font-family: 'Barlow';
  border-top-left-radius: 6px;
  border-top-right-radius: 6px;
  font-size: 20px;
  line-height: 22px !important;
}

.metastatic-sub-heading {
  color: #5B305D;
  font-size: 16px;
  font-weight: 800;
  font-family: 'Barlow', 'sans-serif';
  padding-bottom: 3px;
  border-bottom: 1px solid #5B305D;
  border-width: 1px;
  text-align: center;
  width: 101px;
  margin: 0 auto;
}

.metastatic-indication-text {
  font-size: 14px;
  line-height: 16px !important;
  letter-spacing: -0.28px;
  margin-top: 7px;
}

#test-know-treat.section-4 p.subhead {
  margin-top: 32px;
}
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(1):hover,*/
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(2):hover,*/
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(3):hover,*/
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(4):hover {*/
  /*    transition:0.5s;
  }*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(1):hover .resectable-heading-block {*/
  /*    background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/green-arrow-shape-solid.svg) no-repeat;*/
  /*    background-size: 100%;*/
  /*    min-height: 128px;*/
  /*    position: absolute;*/
  /*    min-width: 210px;*/
  /*    top: -49px;*/
  /*    margin: 0 auto;*/
  /*    padding-top: 20px;*/
  /*    margin-top: 0;*/
  /*    left: 6px;*/
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(1):hover .resectable {*/
  /*    background: #5B305D;*/
  /*    position: relative;*/
  /*    top: -55px;*/
  /*    border-radius: 10px;*/
  /*    min-width: 220px;*/
  /*    width: 100%;*/
  /*    height: 395px;*/
  /*    top: -33px;*/
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(1):hover .resectable-heading {*/
  /*    padding-top: 18px;*/
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(1):hover .resectable-body-block {*/
  /*    padding-top: 65px;*/
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(1):hover .resectable-sub-heading {*/
  /*    color: #fff;*/
  /*    font-size: 24px;*/
  /*    font-weight: 800;*/
  /*    font-family: 'Barlow', 'sans-serif';*/
  /*    padding-bottom: 11px;*/
  /*    border-width: 3px;*/
  /*    text-align: center;*/
  /*    width: 130px;*/
  /*    margin: 0 auto;*/
  /*    width: 100px;*/
  /*    margin-top: 23px;*/
  /*    padding-bottom: 8px;*/
  /*    border-bottom: 1px solid #9c879d;*/
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(1):hover .resectable-indication-text{*/
  /*    font-size: 15px;*/
  /*    line-height: 19px !important;*/
  /*    letter-spacing: -0.3px;*/
  /*    font-weight: 400;*/
  /*    padding-left: 14px;*/
  /*    padding-right: 14px;*/
  /*    margin-top: 16px;*/
  /*    color: #FFFFFF;*/
  /*    font-family: 'Barlow', 'sans-serif';*/
  /*}*/
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(1):hover .unresectable {*/
  /*    background: #f1f1f1;*/
  /*    position: relative;*/
  /*    top: -55px;*/
  /*    border-radius: 10px;*/
  /*    min-width: 220px;*/
  /*    padding-bottom: 6px;*/
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(1):hover .unresectable-heading-block {*/
  /*    background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/green-arrow-shape.svg) no-repeat;*/
  /*    background-size: 100%;*/
  /*    min-height: 110px;*/
  /*    margin-top: -49px;*/
  /*    padding-top: 22px;*/
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(1):hover .unresectable-efficacy .indication-block-desktop-animation a:nth-child(2) .resectable {*/
  /*    background: #f1f1f1;*/
  /*    position: relative;*/
  /*    top: 23px;*/
  /*    border-radius: 10px;*/
  /*    min-width: 220px;*/
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(1):hover .unresectable-heading {*/
  /*        display: block;*/
  /*        align-items: center;*/
  /*        justify-content: center;*/
  /*        color: #5B305D;*/
  /*        font-weight: bold;*/
  /*        font-family: 'Barlow';*/
  /*        border-top-left-radius: 6px;*/
  /*        border-top-right-radius: 6px;*/
  /*        font-size: 20px;*/
  /*        line-height: 22px !important;*/
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(1):hover .unresectable-sub-heading {*/
  /*    padding-top: 35px;*/
  /*    color: #5B305D;*/
  /*    font-size: 16px;*/
  /*    font-weight: 800;*/
  /*    font-family: 'Barlow', 'sans-serif';*/
  /*    padding-bottom: 3px;*/
  /*    border-bottom: 1px solid #5B305D;*/
  /*    border-width: 1px;*/
  /*    text-align: center;*/
  /*    width: 101px;*/
  /*    margin: 0 auto;*/
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(1):hover .unresectable-indication-text {*/
  /*    font-size: 14px;*/
  /*    font-family: 'Barlow', 'sans-serif';*/
  /*    color: #333333;*/
  /*    padding: 6px;*/
  /*    line-height: 16px !important;*/
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(3):hover .locally-metastatic-body-block, */
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(4):hover .metastatic-body-block {*/
  /*    padding-top: 45px;*/
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(3):hover .locally-metastatic,*/
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(4):hover .metastatic {*/
  /*    background: #5B305D;*/
  /*    position: relative;*/
  /*    border-radius: 10px;*/
  /*    min-width: 220px;*/
  /*    width: 100%;*/
  /*    height: 390px;*/
  /*    top: -28px;*/
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(3):hover .locally-metastatic-heading-block,*/
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(4):hover .metastatic-heading-block {*/
  /*    background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/blue-arrow-shape-solid.svg) no-repeat;*/
  /*    background-size: 95%;*/
  /*    min-height: 128px;*/
  /*    position: absolute;*/
  /*    min-width: 210px;*/
  /*    top: -45px;*/
  /*    margin: 0 auto;*/
  /*    padding-top: 16px;*/
  /*    margin-top: 0;*/
  /*    left: 10px; */
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(3):hover .locally-metastatic-heading,*/
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(4):hover .metastatic-heading {*/
  /*    display: block;*/
  /*    align-items: center;*/
  /*    justify-content: center;*/
  /*    color: #fff;*/
  /*    font-weight: bold;*/
  /*    font-family: 'Barlow';*/
  /*    border-top-left-radius: 6px;*/
  /*    border-top-right-radius: 6px;*/
  /*    font-size: 22px;*/
  /*    line-height: 24px !important;*/
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(3):hover .locally-metastatic-sub-heading,*/
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(4):hover .metastatic-sub-heading {*/
  /*    color: #fff;*/
  /*    font-size: 24px;*/
  /*    font-weight: 800;*/
  /*    font-family: 'Barlow', 'sans-serif';*/
  /*    padding-bottom: 11px;*/
  /*    border-width: 3px;*/
  /*    text-align: center;*/
  /*    width: 130px;*/
  /*    margin: 0 auto;*/
      /* width: 100px; */
  /*    margin-top: 36px;*/
  /*    padding-bottom: 8px;*/
  /*    border-bottom: 1px solid #9c879d;       */
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(3):hover .locally-metastatic-indication-text,*/
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(4):hover .metastatic-indication-text {*/
  /*    font-size: 15px;*/
  /*        line-height: 19px !important;*/
  /*        letter-spacing: -0.3px;*/
  /*        font-weight: 400;*/
  /*        padding-left: 14px;*/
  /*        padding-right: 14px;*/
  /*        margin-top: 16px;*/
  /*        color: #FFFFFF;*/
  /*        font-family: 'Barlow', 'sans-serif';*/
  /*}*/
  
  /*.unresectable-efficacy .indication-block-desktop-animation a:nth-child(3):hover .locally-metastatic-body-block .footnote {*/
  /*    color: #fff;*/
  /*}*/
  
  /*animation for indication table*/
  
 /*29-04-25 Start*/
  
.unresectable-efficacy .polygon {
  border-radius: 6px;
  clip-path: polygon(50% 0%, 100% 100%, 0% 100%);
  clip-path: polygon(50% 0%, 100% 38%, 82% 100%, 18% 100%, 0% 38%);
  clip-path: polygon(50% 0%, 100% 38%, 82% 100%, 18% 100%, 0% 38%);
  width: 163px;
  height: 96px;
  border-radius: 5px;
  background: #5b305d;
  -webkit-clip-path: polygon(10% 0%, 90% 0%, 100% 50%, 90% 100%, 10% 100%, 0% 50%);
  clip-path: polygon(0% 0%, 93% 0%, 100% 50%, 93% 100%, 0% 100%, 0% 50%);
  left: 0 !important;
  position: relative;
  top: -7px;
}

.unresectable-efficacy .polygon p {
  text-align: center;
  color: #ffffff;
  margin: 15px auto;
  font-weight: 500;
}

.unresectable-efficacy .effi-nsclc {
  padding-right: 0.2em;
}


/*29-04-25 End*/

  
@media screen and (min-width:991px) {
    
  
  .unresectable-efficacy  #var-3.laurel-targ .green-banner::after {
    transform: skew(-23deg, 0deg);
    border-radius: 10px 14px 14px 6px;
  }

  .unresectable-efficacy  .mdt-molecular-content p {
    margin-bottom: 20px;
  }

  .efficacy.unresectable-efficacy img.nccn-badge {
    max-width: 100%;
  }

  .unresectable-efficacy .laurel-targ p.callout.ffb-sb.is-visible {
    padding: 10px 0;
  }

  .unresectable-efficacy #new-lesion-sites .laurel-targ .green-banner::after {
    transform: skew(-24deg, 0deg);
    border-radius: 10px 14px 15px 6px;
  }

  .unresectable-efficacy #new-lesion-sites .laurel-targ .green-banner {
    background: none;
    margin: 30px 0;
  }

  .footer-notes-tagisso.new-small-note {
    margin: 20px 0 50px  !important;
  }

  .unresectable-efficacy .subhead.new-subhead {
    margin-bottom: 0px;
  }

  .unresectable-efficacy .signi-stats-container .signi-stats .data-copy {
    padding: 15px 0;
  }

  .unresectable-efficacy  span.extrabold.copy-content-lg.surviva-txt {
    margin-bottom: 8px !important;
    display: inline-block;
  }
  
  /*.unresectable-efficacy .signi-stats-container .signi-stats .copy-per p {*/
  /*  padding: 30px 0px 0 3px !important;*/
  /*  }*/
  
  .unresectable-efficacy .pfs-container {
    margin-top: 30px;
  }

  .unresectable-efficacy .pfs-container .pfs-content td {
    padding: 5px 10px;
  }

  .unresectable-efficacy .mdt-molecular-container .mdt-molecular-content .pathologic-nsldc {
    padding-left: 13px;
  }

  .pathologic-nsldc li:before {
    margin-left: 0px;
  }
    
    /*nccn block*/
  .unresectable-efficacy #pfss .nccn-block {
    margin: 40px 0 15px 0;
  }

  .slide-frm-right {
          /* transform: translate(130%); */
    transform: translate(46%);
  }
      
      /*.is-visible .slide-frm-left, .is-visible .slide-frm-right {*/
      /*    transition: 1.25s all cubic-bezier(0, 0, 0, 0.79);*/
      /*    transform: none;*/
      /*    opacity: 1;*/
      /*}*/
  .mn-nccn-head-tall-new {
          /*background: url(/content/dam/open-digital/tagrisso-hcp/us/en/global/nccn-chevron-tall-desktop.png) no-repeat;*/
    background: url(/content/dam/open-digital/tagrisso-hcp/us/en/global/NCCN%20Purple%20Chevron.Desktop.png) no-repeat;
    width: 120px;
    height: 131px;
    left: 13px;
    background-size: contain;
  }

  .unresectable-efficacy .mn-nccn-content {
    background: #F1F1F1;
          /* padding: 15px 30px 8px 11px; */
    padding: 4px 30px 6px 11px;
    max-width: 578px;
          /* height: 133px; */
    margin-left: 25px;
    margin-top: -62px;
  }
      /*.unresectable-efficacy .mn-nccn-content:before {*/
      /*    width: 16px !important;*/
      /*    left: -10px !important;*/
      /*    background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/leftcurve-grey.png) no-repeat;*/
      /*    height: 70px;*/
      /*    background-size: contain;*/
      /*}*/
  .unresectable-efficacy .content, .metastatic-nsclc.egf .section-10 ul li {
    font-size: 16px;
    line-height: 20px !important;
    margin: 0;
  }

  .laura-nsclc .isi-wrapper.open {
    z-index: 1;
    margin-top: -21px;
  }

  .unresectable-efficacy .nccn-content {
    font-size: 16px;
    line-height: 20px !important;
    padding: 19px 31px 19px 45px;
    background: #f1f1f1;
    margin-top: -5px;
  }

  .unresectable-efficacy .nccn-content, .unresectable-efficacy img.nccn-badge {
          /*height:105px;*/
    ;
  }
      
      /*.slide-frm-left {*/
      /*    transform: translate(-20vw);*/
      /*}*/
      /*.slide-frm-right {*/
          /* transform: translate(130%); */
      /*    transform: translate(46%);*/
      /*}*/
      /*.is-visible .slide-frm-left, */
      /*.is-visible .slide-frm-right {*/
      /*    transition: 1.25s all cubic-bezier(0, 0, 0, 0.79);*/
      /*    transform: none;*/
      /*    opacity: 1;*/
      /*}*/
  .nccn-content:before {
    content: "";
    background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/leftcurve-grey.png) no-repeat;
    width: 11px;
    height: 90px;
    position: absolute;
    left: -11px;
    top: 0;
  }

  .egfr-banner1.nccn-content:before {
    height: 98px !important;
    background-size: 14px 107px !important;
  }
    /*nccn block*/
    
  p.footnotes.desktop-only.below-nccn {
    margin-left: 42px;
          /*margin-top: -10px;*/
    ;
  }

  .nccn-badge--banner {
    background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/purple-callout-banner.svg);
    background-repeat: no-repeat;
    background-size: auto;
    width: 710px;
    margin: 24px auto 30px;
    padding: 17px 0;
  }

  .nccn-badge-wrapper {
    display: flex;
  }

  h3.nccn-badge--banner-title {
    text-align: center;
    font-size: 16px;
    font-family: 'Barlow';
    font-weight: 700;
    color: white;
    line-height: 22px;
    margin-left: 12px;
    margin-top: auto;
  }

  p.nccn-badge--banner-text {
    font-family: 'Barlow';
    font-size: 16px;
    text-align: left;
    color: #5B305D;
    font-weight: 500;
    flex-basis: 490px;
    margin: 0 auto;
  }

  .nccn-badge--banner .footnotes {
    font-weight: 400;
    font-size: 12px;
    line-height: 16px !important;
    color: #333333;
    text-indent: -5px;
    padding-left: 5px;
    margin: 35px 0 0 !important;
  }

  .unresectable-efficacy .footer-notes-tagisso.new-footnote-nccn {
    margin: 20px 0 40px  !important;
  }

  .unresectable-efficacy .section-2 .page-section-inner.container {
    margin-top: 20px;
    margin-bottom: 0px;
  }

  .unresectable-efficacy .data-maturity.new-footnote {
    max-width: 643px !important;
    padding: 0 !important;
    margin: 0 auto !important;
  }

  .unresectable-efficacy .data-maturity.new-footnote ul.bullet-list li:first-child {
    padding: 0;
  }

  .unresectable-efficacy  #var-2.laurel-targ .green-banner::after {
    transform: skew(-23deg, 0deg);
    border-radius: 10px 14px 14px 6px;
  }

  .unresectable-efficacy #var-2.laurel-targ .green-banner {
    background: none !important;
  }

  .new-image.km-curve-18\.9.progression-survival-graph.new-graph-margin {
    padding-bottom: 20px;
  }

  .unresectable-efficacy .signi-stats-container {
    margin-top: 30px !important;
  }

  .unresectable-efficacy .cns-aura3-vertical-graph {
    margin-top: 31px;
  }

  .efficacy.unresectable-efficacy .mdt-molecular-container .mdt-molecular-content .pathologic-nsldc.bullet-list {
    margin-top: 0px;
  }
}

@media screen and (max-width:991px) {
    
    
       @keyframes scale-upm {
            from {
             
              transform: none;
            }
            to {
             
              transform: scale(1.5);
              
            }
          }
          
          
      .unresectable-efficacy .targisso-intro-container .targisso-intro h2, h2.slide-to-top{
          font-size: 24px;
    line-height: 30px;
      }
  .laura-nsclc .isiNode ul.isi-list ul {
          /*padding-left: 0px;*/
    padding-left: 3px;
  }

  .unresectable-efficacy .signi-stats-container .signi-stats .data-copy .copy-content .copy-content-sm.vs-txt {
    font-size: 14px !important;
    line-height: 17px !important;
  }

  .unresectable-efficacy span.extrabold.hr-txt.purple-txt {
    font-size: 14px;
    line-height: 17px;
  }

  .unresectable-efficacy ul.bullet-list {
    margin-bottom: 0px;
      /*margin-left: 15px !important;*/
    ;
  }

  .unresectable-efficacy .targisso-endpoint-container p {
    margin-bottom: 15px;
  }

  .unresectable-efficacy #pfss .data-maturity.new-maturity ul.bullet-list {
    margin-left: 21px !important;
    margin-right: 15px;
  }

  .unresectable-efficacy span.hr-txt.purple-txt {
    font-size: 14px;
    line-height: 17px;
  }

  p.footnotes.new-footnote-laurel {
    padding: 0 15px;
    margin: 0px 0 40px;
    padding-right: 20px;
  }

  .unresectable-efficacy #new-lesion-sites .laurel-targ p.callout.ffb-sb.is-visible {
    padding-right: 50px;
    padding-top: 10px;
    padding-bottom: 10px;
  }

  .unresectable-efficacy .bar-graph-mobile {
    text-align: center;
  }

  .unresectable-efficacy .bar-graph-mobile img {
    width: 90%;
  }

  .unresectable-efficacy .data-maturity.data-maturity2 ul.bullet-list {
    padding: 0 15px;
  }

  .unresectable-efficacy  .targisso-intro-container.vari-3 {
    margin: 40px 15px 10px;
  }

  p.newlesions-title-mobile.mobile-only {
    text-align: center;
    font-family: 'Barlow';
    font-size: 15px;
    color: #333;
    margin: 0 !important;
    font-weight: 600;
    margin-bottom: 20px !important;
  }

  .newlesions-graphics-img.mobile-only {
    margin: 0px 0 20px;
    width: 100%;
    padding-left: 37px;
    padding-right: 63px;
  }

  .unresectable-efficacy .section-2 .page-section-inner.container {
    margin-bottom: 10px;
  }

  .unresectable-efficacy #subgroups .eyebrow,
    .unresectable-efficacy #subgroups h2.slide-to-top {
    padding: 0 10px;
  }

  .unresectable-efficacy #new-lesion-sites .eyebrow,
    .unresectable-efficacy #new-lesion-sites h2.slide-to-top,
    .unresectable-efficacy #new-lesion-sites .subhead,
    .unresectable-efficacy #ttdm .subhead {
    padding: 0 18px;
  }
  

  .unresectable-efficacy #test-know-treat h2.slide-to-top,
    .unresectable-efficacy #test-know-treat .subhead {
    padding: 0 20px;
  }

  .efficacy.unresectable-efficacy #test-know-treat h2.slide-to-top.assume-mutation.is-visible {
    margin-top: 40px;
  }

  .unresectable-efficacy .subhead {
    padding: 0 0px;
  }
  .unresectable-efficacy #subgroups h2.assume-mutation.mt-20{
            margin-top: 20px;
    }
.unresectable-efficacy #new-lesion-sites h2.slide-to-top.mt-20{
    margin-top: 20px;
}
  .unresectable-efficacy #tagrisso-approvals .subhead {
        /*padding: 0 20px;*/
    padding: 10px 20px 0;
  }

  #tagrisso-approvals h2.slide-to-top {
    margin-bottom: 20px;
  }

  h2.slide-to-top {
    padding: 0 20px;
  }

  .nccn-badge-wrapper {
    display: flex;
    flex-direction: column;
    padding: 0px 15px 24px 30px;
  }

  .nccn-badge--banner {
    background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/purple-callout-banner-mobile.svg);
    background-repeat: no-repeat;
    background-size: auto;
    width: 252px;
    margin: 24px auto 0;
    padding: 17px 0;
  }

  h3.nccn-badge--banner-title {
    font-family: 'Barlow';
    font-size: 16px;
    color: #fff;
    margin-top: -6px;
    text-align: center;
    font-weight: 700;
    line-height: 19px;
    margin-bottom: 50px;
    margin-left: -12px;
  }

  p.nccn-badge--banner-text {
    font-family: 'Barlow';
    font-size: 16px;
    line-height: 20px !important;
    color: #5B305D;
    text-align: left;
  }

  .unresectable-efficacy .signi-stats-container .signi-stats .data-copy .copy-content {
    margin-bottom: 12px;
    margin-left: 0px !important;
    margin-top: 10px;
    transform: none;
  }

  .unresectable-efficacy .signi-stats-container .signi-stats .data-copy .copy-content .extrabold.copy-content-lg.surviva-txt {
        /*display: inline-block !important;*/
    font-size: 30px !important;
    line-height: 31px !important;
    margin-bottom: 8px;
  }

  .signi-stats-container .copy-content-lg {
    font-size: 30px;
    line-height: 30px;
  }

  .unresectable-efficacy .pfs-container {
    margin-bottom: 30px;
  }

  .footer-notes-tagisso.mobile-only.new-footnote-ncn {
        /*margin: 0 10px 60px 10px;*/
    margin: 0 10px 60px 10px;
  }

  .unresectable-efficacy #pfss .footer-notes-tagisso.mobile-only.new-footnote-ncn {
    margin-bottom: 15px;
  }

  .unresectable-efficacy .data-maturity {
    margin: 0 !important;
  }

  .unresectable-efficacy .pfs-container .pfs-content {
    padding-top: 5px !important;
  }

  .unresectable-efficacy .data-maturity.new-maturity ul.bullet-list-dash {
    list-style-type: none !important;
    padding-left: 10px;
  }

  .unresectable-efficacy .column-text {
    font-size: 16px;
    line-height: 20px;
    color: #333333;
    font-family: 'Barlow';
    font-weight: 500;
    text-align: center;
    margin-bottom: 30px;
  }

  .unresectable-efficacy #test-know-treat {
    padding-top: 0px !important;
    scroll-margin-top: -25px;
  }

  .unresectable-efficacy #laura-study-design  .last-footnote {
    margin-bottom: 20px !important;
  }

  .unresectable-efficacy #laura-study-design.section-2 .last-footnote {
    font-weight: 400;
    font-size: 12px;
    color: #333333;
    font-family: 'Barlow';
    text-indent: -3px;
    margin-left: 0px;
    line-height: 16px !important;
  }

  .unresectable-efficacy .startisifact-container .startisifact-content {
    margin-top: 40px !important;
  }

  .mtop_10 {
    /*margin-top: 20px !important;*/
    margin-top: 30px !important;
  }
}

.unresectable-efficacy #test-know-treat::before {
  box-shadow: none;
}
  /* updates end */
.unresectable-efficacy .targisso-intro-container .targisso-intro h2, h2.slide-to-top {
  font-weight: 800;
  font-size: 30px;
  line-height: 36px;
  color: #5B305D;
  margin-top: 0px;
    /*margin-top: 5px;*/
  margin-bottom: 25px;
}
.unresectable-efficacy .targisso-intro-container .targisso-intro h2.no-padd-left{
    padding-left:0;
}

.targisso-intro-container h2.slide-to-top {
  max-width: 800px;
}

.unresectable-efficacy #new-lesion-sites .targisso-intro-container .targisso-intro h2 {
  margin-bottom: 30px;
}

.unresectable-efficacy #laura-study-design {
      /*margin-top: 70px;*/
  padding-top: 65px;
  padding-bottom: 0px;
  margin-bottom: -44px;
}

.unresectable-efficacy #test-know-treat {
  padding-top: 60px;
      /*padding-bottom: 70px;*/
  padding-bottom: 45px;
  z-index: 1;
  margin-bottom: -30px;
}

.unresectable-efficacy .signi-stats-container {
  max-width: 710px;
}
  
  /*.unresectable-efficacy .green-banner.is-visible {*/
  /*    transform: none;*/
  /*}*/
  
.unresectable-efficacy .signi-stats-container .signi-stats .data-copy {
    /* padding: 15px;
    border-top-left-radius: 20px;
    border-top-right-radius: 20px;
    padding-bottom: 10px; */
  background: #F1F1F1;
  border-top-left-radius: 20px;
  border-top-right-radius: 20px;
  overflow: hidden;
  padding: 20px;
  padding-left: 23px;
  padding-bottom: 0;
}

.unresectable-efficacy .copy-content {
  margin-bottom: 16px;
  margin-left: 2px;
    /*transform: translate3d(100%, 0, 0);*/
  transform: translate3d(104%, 0, 0);
}

.unresectable-efficacy .copy-per {
  max-width: 136px;
      /*background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/shape-80-per.png) no-repeat;*/
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/84%20shape.png) no-repeat;
  width: 100%;
      /*background-color: #fff;*/
  background-size: contain;
  background-position: center;
  transform: translate3d(0, -100%, 0);
  min-height: 95px;
  height: 95px;
  padding: 9px 0px 0px 0;
  margin-top: 5px;
}

.is-visible .copy-per, 
  .is-visible .copy-content {
  transform: translate3d(0, 0, 0);
  transition: all 1.5s ease;
}

.unresectable-efficacy .signi-stats-container .signi-stats .copy-per p {
      /*font: normal normal 700 72px / 73px Barlow;*/
  font: normal normal 700 69px / 21px Barlow;
  text-align: center;
  padding: 24px 0px 0 3px;
  font-weight: 700 !important;
}

.unresectable-efficacy .copy-per p sup {
  font-size: 65%;
}

.unresectable-efficacy .signi-stats-container .signi-stats .data-copy .copy-content .extrabold.copy-content-lg.surviva-txt {
  font-size: 28px;
  line-height: 22px;
  font-weight: 800 !important;
}

span.copy-content-lg.surviva-txt.nowrap {
  font-weight: 500 !important;
  margin-bottom: 22px !important;
  line-height: 22px;
}

.unresectable-efficacy .signi-stats-container .signi-stats .data-copy .copy-content .placebo {
  font-size: 22px;
  line-height: 22px;
  display: block;
  font-weight: 500;
}

.unresectable-efficacy .copy-content .ffb-med {
  font-weight: 500 !important;
  font-size: 15px;
}

.unresectable-efficacy .signi-stats-container .signi-stats .data-copy .copy-content .copy-content-sm.vs-txt {
  font-size: 15px;
  line-height: 22px;
}

.unresectable-efficacy .pfs-container {
  background: #F1F1F1;
  max-width: 526px;
  padding: 1px 0;
}

.unresectable-efficacy .pfs-container .pfs-content {
  text-align: center;
  padding-top: 13px;
  padding-bottom: 4px;
}

.unresectable-efficacy .pfs-container .pfs-content h4 {
  font: normal normal 800 14px/18px 'Barlow';
  color: #333333;
  margin-bottom: 14px;
}

.unresectable-efficacy .pfs-container .pfs-content .pfs-data {
  width: 88%;
}

.unresectable-efficacy .pfs-container .pfs-content .pfs-data th:nth-child(2) {
  color: #5B305D;
  font-weight: 700;
}

.unresectable-efficacy .pfs-container .pfs-content .pfs-data td:nth-child(2) {
  color: #5B305D;
  font-size: 20px;
}

.unresectable-efficacy .pfs-container .pfs-content .pfs-data tr {
  border-bottom: 1px solid;
}

.unresectable-efficacy .pfs-container .pfs-content .pfs-data th,
  .unresectable-efficacy .pfs-container .pfs-content .pfs-data td {
  text-align: center;
  color: #333333;
  font-size: 18px;
  line-height: 24px;
  font-weight: 600;
}

.unresectable-efficacy .pfs-container .pfs-content .pfs-data th {
  padding-bottom: 7px;
  font-weight: 500;
}

.unresectable-efficacy .pfs-container > div > table > tbody > tr:nth-child(1) > th:nth-child(1) {
  text-align: left;
  font-weight: 500;
}

.unresectable-efficacy .pfs-container .pfs-content .pfs-data tr td:first-child {
  text-align: left;
  padding-left: 0px;
}

.unresectable-efficacy .pfs-container .pfs-content .pfs-data td {
  font-weight: 500;
  font-size: 20px;
}

.unresectable-efficacy .pfs-container .pfs-content .pfs-data td span {
  display: block;
  font-weight: 300;
  font-size: 13px;
}

.unresectable-efficacy .pfs-container .pfs-content p {
  text-align: center;
  font-size: 16px;
  line-height: 20px;
  padding: 5px 0;
  padding-top: 23px;
  font: normal normal normal 16px / 20px 'Barlow';
  color: #000;
}

.data-maturity .bullet-list li .bicr {
  display: block;
}

.unresectable-efficacy .data-maturity {
  max-width: 813px;
  padding: 27px 0px 0px 0px;
  margin-left: 0px;
    /*padding: 20px 0;*/
  ;
}

.unresectable-efficacy .laurel-targ .green-banner {
  margin: 20px 0;
}

.unresectable-efficacy .footer-notes-tagisso {
  margin: 0 0 50px 0;
}

.unresectable-efficacy .signi-stats-container-2 {
  max-width: 700px;
}

.unresectable-efficacy .signi-stats-container-2 .signi-stats-2 {
  max-width: 646px;
}
  
  /*.unresectable-efficacy ul.bullet-list {*/
  /*  margin-bottom: 0px;*/
  /*  margin-left: 0px !important;*/
  /*}*/
  
.unresectable-efficacy .targisso-endpoint-container p {
  margin-bottom: 20px;
}

.unresectable-efficacy ul.bullet-list li:first-child {
  padding-bottom: 20px;
}

.unresectable-efficacy #laura-study-design.section-2 div.data-maturity.data-maturity3 ul.bullet-list li:first-child {
  margin-left: 8px;
}

.unresectable-efficacy .mdt-molecular-container .mdt-molecular-content .pathologic-nsldc {
  margin-left: -2px !important;
}

.unresectable-efficacy ul.bullet-list li.second-li-nw {
  padding-bottom: 20px;
}
  /*.unresectable-efficacy ul.bullet-list li {*/
  /*    margin-bottom: 15px;*/
  /*}*/
  
.unresectable-efficacy .signi-stats-container-2 .signi-stats-2 .data-copy {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/efficacy/Brain-and-Callout-Background-Desktop.png) no-repeat;
  color: #FFFFFF;
  padding: 40px;
}

.unresectable-efficacy .signi-stats-container-2 .signi-stats-2 .data-copy .copy-per {
  background: none;
  max-width: 150px;
  padding: 0px;
  margin-left: 75px;
}

.unresectable-efficacy .signi-stats-container-2 .signi-stats-2 .data-copy .copy-content-2 {
  margin-left: -15px;
}

.unresectable-efficacy .signi-stats-container-2 .signi-stats-2 .data-copy .copy-per p {
  color: #FFFFFF;
  margin-top: 4px;
  font: normal normal bold 64px / 19px 'Barlow';
}

.unresectable-efficacy .signi-stats-container-2 .signi-stats-2 .data-copy .copy-content-2 .extrabold.copy-content-lg.surviva-txt {
  font-size: 22px;
  line-height: 22px;
}

.unresectable-efficacy .signi-stats-container-2 .signi-stats-2 .data-copy .copy-content-2 .ffb-med.vs-txt.vs-txt-new {
  display: block;
  font-size: 16px;
}

.unresectable-efficacy .cns-event .cns-progression {
  text-align: center;
  font-size: 15px;
}

.unresectable-efficacy .copy-content-sm {
  font-size: 16px;
}

.unresectable-efficacy .bar-tag-plac {
  max-width: 813px;
}

.unresectable-efficacy .startisifact-container {
  max-width: 810px;
}

.unresectable-efficacy .startisifact-container .startisifact-content {
  display: flex;
  gap: 10px;
}

.unresectable-efficacy .startisifact-container .startisifact-content > div {
    /*margin-right: 20px;*/
  margin-right: 0px;
  padding-right: 10px;
  padding-left: 3px;
}

.unresectable-efficacy #pfss .panel-body {
  padding: 0px;
}

.unresectable-efficacy #pfss .panel-body p {
  margin-bottom: 0px;
}

.unresectable-efficacy #subgroups .panel-body {
      /*padding: 30px 0px 15px 32px;*/
  padding: 0px;
  padding-left: 15px;
  padding-bottom: 30px;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify,
  .unresectable-efficacy .startisifact-container .startisifact-content .startisify-crt {
  border-right: 2.5px solid #9B9B9B;
}

.unresectable-efficacy .startisifact-container .startisifact-content > div > ul {
  padding-left: 0px;
  list-style: none;
  margin-bottom: 0;
}

.unresectable-efficacy .startisifact-container .startisifact-content > div > ul li {
  font-size: 13px;
  line-height: 15px !important;
}

.unresectable-efficacy .startisifact-container .startisifact-content > div > ul >li:before {
  content: '\2022';
  position: absolute;
  left: -8px;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify {
  max-width: 274px;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify-crt {
  max-width: 328px;
  margin-left: 3px;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify h5,
  .unresectable-efficacy .startisifact-container .startisifact-content .startisify-crt h5 {
  font: normal normal bold 13px/15px 'Barlow';
  color: #3B3C3E;
  margin-bottom: 0;
  margin-top: 0;
}

.unresectable-efficacy .startisifact-container .startisify-placebo p {
  font-size: 13px;
  margin: 0 !important;
  line-height: 15px !important;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify-placebo {
  max-width: 185px;
  margin-top: 0px;
  padding-top: 0px;
}

.unresectable-efficacy .targisso-endpoint-container > p > span {
  font-weight: bold;
}

.unresectable-efficacy .chinese-site p {
  font-size: 12px;
  line-height: 16px !important;
  text-indent: -7px;
}

.unresectable-efficacy .tkt-container {
  max-width: 700px;
}

.unresectable-efficacy .tkt-container .tkt-content {
  display: flex;
  align-items: baseline;
  gap: 25px;
}

.unresectable-efficacy .tkt-container .tkt-content > div > figure {
  width: 106px;
}

.unresectable-efficacy .tkt-container .tkt-content > div > figure > img {
  text-align: center;
}

.unresectable-efficacy .column-1 {
  transform: translateY(85px);
  transition: 1s ease-in-out;
}

.unresectable-efficacy .column-1,
  .unresectable-efficacy .column-2,
  .unresectable-efficacy .column-3 {
  padding: 0px;
  width: 30%;
}
  
  /*.dom-ready .column-1 {*/
  /*    transform: none;*/
  /*}*/
  
.is-visible .column-1 {
  transform: none;
}

.unresectable-efficacy .efficacy-column {
  max-width: 710px;
  margin: 0 auto;
}

.unresectable-efficacy .column-2 {
  transform: translateY(100px);
  transition: 1.7s ease-in-out;
}
  
  /*.dom-ready .column-2 {*/
  /*    transform: none;*/
      /*padding: 0px;*/
      /*width: 30%;*/
  /*}*/
  
.is-visible .column-2 {
  transform: none;
}

.unresectable-efficacy .column-2 img {
  position: relative;
  top: 12px;
}

.unresectable-efficacy .column-3 img {
  position: relative;
  top: 10px;
}

.unresectable-efficacy .column-3 {
  transform: translateY(145px);
  transition: 2s ease-in-out;
}
  
  /*.dom-ready .column-3 {*/
  /*    transform: none;*/
      /*padding: 0px;*/
      /*width: 30%;*/
  /*}*/
  
.is-visible .column-3 {
  transform: none;
}

.unresectable-efficacy .column-head {
  font-size: 36px;
  line-height: 18px;
  color: #5B305D;
  font-family: 'Barlow';
  font-weight: 800;
  padding: 10px 0;
}

.unresectable-efficacy .column-head2 {
  margin-top: 24px;
}

.unresectable-efficacy .column-head3 {
  margin-top: 14px;
}

.unresectable-efficacy .column-text {
  font-size: 16px;
  line-height: 20px;
  color: #333333;
  font-family: 'Barlow';
  font-weight: 500;
  text-align: center;
}

.unresectable-efficacy .tkt-container .tkt-content .targisso-test-content,
  .unresectable-efficacy .tkt-container .tkt-content .targisso-know-content,
  .unresectable-efficacy .tkt-container .tkt-content .targisso-treat-content {
  display: flex;
  flex-direction: column;
  justify-content: center;
  align-items: center;
}

.unresectable-efficacy .tkt-container .tkt-content .targisso-know-content h4 {
  padding: 20px 0 10px 0;
}

.unresectable-efficacy .mdt-molecular-container {
  padding: 20px 0;
  margin-left: 0px;
}

.unresectable-efficacy .mdt-molecular-container .mdt-molecular-content .data-maturity {
  padding: 0;
  padding-left: 10px;
}

.unresectable-efficacy .mdt-molecular-container .mdt-molecular-content .data-maturity ul {
  margin: 0;
}

.unresectable-efficacy .mdt-molecular-container .mdt-molecular-content .pathologic-nsldc {
  margin: 0 0 0 0px;
  list-style-type: none;
  padding-left: 27px;
      /*margin-top: -18px;*/
  ;
}

.unresectable-efficacy .tagrisso-laura-trail-cta {
  max-width: 504px;
}

.unresectable-efficacy .tagrisso-laura-trail-cta .visit-btn a {
  padding: 15px 5px;
}

.unresectable-efficacy .laurel-targ .green-banner {
  width: calc((100% + 1730px) / 2);
    /*padding-left: calc((100% + 1784px));*/
  padding-left: calc((100% + 1777px));
}

.unresectable-efficacy .laurel-targ .green-banner.var {
    /*width: calc((100% + 1223px) / 2);*/
  width: calc((100% + 1723px) / 2);
}

.unresectable-efficacy #var-2.laurel-targ .green-banner {
  width: calc((100% + 2560px));
  margin: 50px 0px 40px 0px;
  padding-left: calc((100% + 1784px));
}

.unresectable-efficacy #laura-study-design .chinese-site {
  margin-bottom: 80px;
}

.unresectable-efficacy #laura-study-design  .last-footnote {
  margin-bottom: 70px;
  left: 0px;
  text-indent: -4px;
  font-family: 'Barlow';
  margin-left: 2px;
}

.unresectable-efficacy .footnotes {
  font-family: 'Barlow';
}

.unresectable-efficacy #laura-study-design .egfr-chemor {
  margin-top: 20px;
}

.unresectable-efficacy #var-3.laurel-targ .green-banner {
  width: calc((100% + 2560px));
  margin: 7px 0px 40px;
  background: none;
}

.unresectable-efficacy .bar-tag-plac .cns-prerc-graph,
  .unresectable-efficacy .foot-note-botttom.mobile-only {
  display: none;
}

.unresectable-efficacy .green-banner {
  padding-right: 47px;
  width: calc((100% + 2600px));
  padding-left: calc((100% + 1813px));
  margin: 25px 0 30px 0;
}

.visit-btn {
  max-width: 550px;
  margin: 50px auto 0px;
}

.visit-btn .primary-button {
  padding-top: 12px;
  padding-bottom: 12px;
}

.pathologic-nsldc {
  list-style-type: none;
}

.pathologic-nsldc li:before {
  content: '\2014';
  margin-left: -9px;
  position: absolute;
  margin-left: -15px;
}

@media screen and (max-width: 991px) {
  body, html {
        /*overflow-y: scroll;*/
    overflow-x: hidden;
  }

  #pfs, .unresectable-efficacy #pfss {
    margin-top: 76px;
    padding-top: 0px;
    overflow: hidden;
      /*min-height: 200px;*/
      /*height:132px;*/
      /*position: absolute;*/
    ;
  }

  .efficacy.unresectable-efficacy #pfs {
    height: 132px;
    margin-top: 50px;
    padding-top: 13px;
  }

  .unresectable-efficacy .green-banner.is-visible {
    transform: none;
    width: 80%;
    /*padding: 12px 5px 12px 35px;*/
    padding: 12px 5px 12px 40px;
  }

  .unresectable-efficacy .page-section-inner {
    max-width: 950px;
  }
  
  /*.unresectable-efficacy.dom-ready .banner-bg-section:after {*/
  /*    transform: scale(1.5);*/
  /*    background-size: cover;*/
  /*    height: 100px;*/
  /*}*/
  
  .unresectable-efficacy .mdt-molecular-container .mdt-molecular-content .pathologic-nsldc {
    padding-left: 13px;
  }

  .pathologic-nsldc li:before {
    margin-left: 0px;
  }

  .unresectable-efficacy .banner-bg-section:after {
          /*transition: 1s ease;*/
          /*background-size: cover;*/
                  /*height: 132px;*/
    height: 100%;
    display: block;
        /*background-position-y: -10px;*/
  }
      
      @  keyframes scale-upm {
    from {
              /*background-size: 125% auto;*/
              /*background-position-y: 16px;*/
              transform: none;
  }

  to {
              /*background-size: 380% auto;*/
    transform: scale(1.5);
              /*background-position-y: -14px;*/
    ;
  }
}

.dom-ready.unresectable-efficacy .banner-bg-section:after {
  animation: 2.5s linear forwards scale-upm;
          /* transform: scale(2); */
    /* transform: scale(2.5); */
    /*transform: scale(1.5);*/
  background-size: cover;
  background-position-y: 4px;
    /*animation:none;*/
  ;
}
  
    /*  .dom-ready.unresectable-efficacy .banner-bg-section:after {*/
        /* transform: scale(2); */
        /* transform: scale(2.5); */
    /*    transform: scale(1.5);*/
    /*}*/
  
      /*.dom-ready .banner-bg-section:after {*/
          /*transform: scale(2.5);*/
          /*background-position-y: 22px;*/
          /*transition: all 2s ease;*/
          /*background-size: cover;*/
          
          /*background-position-y: -14px;*/
      /*}*/
  
.unresectable-efficacy #pfss {
      /*margin-top: 179px;*/
  margin-top: 186px;
      /*scroll-margin-top: 200px;*/
  padding: 10px;
  position: relative;
      /*overflow: hidden;*/
  overflow: inherit;
}

.laura-nsclc .section-heading-mobile {
  z-index: 99999;
}

.unresectable-efficacy #subgroups {
  padding: 0 10px;
  padding-bottom: 25px;
  z-index: 1;
  padding-top: 40px;
}

.unresectable-efficacy .targisso-intro-container {
  margin: 0px 11px 10px;
}

.unresectable-efficacy .signi-stats-container .signi-stats,
    .unresectable-efficacy .pfs-container .pfs-content,
    .unresectable-efficacy .targisso-endpoint-container,
    .unresectable-efficacy .chinese-site p,
    .unresectable-efficacy .foot-note-botttom.mobile-only {
  margin: 0 10px;
}

.unresectable-efficacy .targisso-endpoint-container {
        /*margin: 0 20px;*/
  margin: 0 15px;
}

.unresectable-efficacy .data-maturity {
  margin: 0 8px;
  padding: 0;
  margin-top: 14px;
}

.unresectable-efficacy .data-maturity3 {
  margin: 0 12px !important;
        /*margin-left: -2px !important;*/
  ;
}

.unresectable-efficacy .data-maturity2 {
  margin: 0 15px;
  margin-top: 25px;
}

.unresectable-efficacy .targisso-intro>h1 {
  margin-top: 15px;
  margin-bottom: 20px;
}

.unresectable-efficacy img.new-indication {
  position: relative;
  width: 100%;
  float: right;
  clear: both;
  margin-right: 0px;
  top: 36px;
  left: -10px;
  margin-top: -203px;
  transform: translate(0);
}

.unresectable-efficacy #pfss img.new-indication {
          /*width: 100%;*/
          /*left: -10px;*/
          /*height: auto;*/
            /*width: 100%;*/
            /*left: -12px;*/
            /*height: auto;*/
            /*top: 84px;*/
  max-width: 300px;
 /*newly added (20-11-24)*/
  width: 100%;
  left: -19px;
  height: auto;
  top: 94px;
  max-width: 300px;
}

.unresectable-efficacy .signi-stats-container .signi-stats .copy-per {
  max-width: 150px;
  padding: 18px;
  background-position: center;
  background-size: 82%;
  background-position: center;
  transform: none;
}

.unresectable-efficacy .grey-content {
  color: #5A5B5E;
  font-size: 14px;
}

.panel-default>.panel-heading+.panel-collapse>.panel-body {
  padding: 5px;
}

.unresectable-efficacy #pfss .targisso-intro-container .targisso-intro {
      /*margin-top: -107px;*/
  /*margin-top: 106px;*/
  ;
}

.unresectable-efficacy .copy-per p {
  font: normal normal 700 61px / 42px 'Barlow' !important;
}

.unresectable-efficacy .signi-stats-container .signi-stats .copy-per p {
  padding: 0px 0px 0 6px;
}

.unresectable-efficacy .copy-per p sup {
  font-size: 58%;
}

.accordion.section .accordion-container {
  width: 95%;
}

.unresectable-efficacy .egfr-chemor {
  margin: 0 15px;
}

.unresectable-efficacy .signi-stats-container .signi-stats .data-copy {
  padding: 15px;
  border-top-left-radius: 20px;
  border-top-right-radius: 20px;
  padding-bottom: 0px;
  padding-top: 10px;
  background: #F1F1F1;
  padding-left: 10px;
  padding-right: 10px;
}

.nccn-block-mob p {
  background: #f1f1f1;
  font-size: 16px;
  line-height: 20px !important;
  margin-top: -40px;
  padding-top: 40px;
}
  
  /*nccn block*/
.nccn-block-mob-nobg {
  background: none;
  margin-bottom: 39px;
}

.unresectable-efficacy .nccn-content-mob-gray-tall-2 {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/mobile/2x-nccn-gray-banner-tall-mobile.png) no-repeat !important;
  background-position-x: 0px !important;
  background-position-y: 2px !important;
  background-size: 100% !important;
  position: relative;
  top: 42px;
}

.nccn-block-mob p {
  background: #f1f1f1;
  font-size: 16px;
  line-height: 20px !important;
  margin-top: -40px;
  padding-top: 40px;
}

.footer-notes-tagisso.mobile-only.new-footnote-ncn p.footnotes.mobile-only {
  text-indent: -4px;
  margin-left: 6px;
}
  /*nccn block*/
  
.unresectable-efficacy .pfs-container .pfs-content .pfs-data td {
  text-align: center;
  color: #333333;
  font-size: 15px;
  line-height: 15px;
  padding: 10px 5px;
}

.unresectable-efficacy table.pfs-data b {
  line-height: 1.2;
  font-size: 20px;
}

.unresectable-efficacy .pfs-container .pfs-content .pfs-data tr td:first-child {
  text-align: left;
  padding-left: 0px;
  font-size: 16px;
}

.unresectable-efficacy .pfs-container .pfs-content .pfs-data tr td:first-child,
  .unresectable-efficacy .pfs-container .pfs-content .pfs-data tr th:first-child {
  text-align: left;
}

.unresectable-efficacy .pfs-container .pfs-content h4 {
  font-size: 15px;
  line-height: 18px;
  color: #333333;
  font-weight: 600;
}

.unresectable-efficacy .pfs-container {
  background: #F1F1F1;
  max-width: 93%;
  padding: 1px 0;
  width: 100%;
  padding-top: 1px;
  padding-bottom: 1px;
}

.unresectable-efficacy .pfs-container .pfs-content .pfs-data {
  margin: 0 auto;
  width: 96%;
}

.unresectable-efficacy .pfs-container .pfs-content p {
  padding-top: 11px;
  padding-bottom: 0;
  color: #333;
}

.laurel-targ {
  margin-left: -4px;
}
    /*.unresectable-efficacy .data-maturity {*/
    /*  max-width: 325px;*/
    /*}*/
  
.unresectable-efficacy .laurel-targ .green-banner, .unresectable-efficacy .laurel-targ .green-banner.var {
  margin: 20px 0 30px 0;
  width: 89%;
  padding: 2px 0px 4px 52px;
  transform: none;
}

.unresectable-efficacy .laurel-targ .green-banner {
  margin: 14px 0 20px 0;
  width: 90%;
  padding: 12px 0px 22px 36px;
}

.unresectable-efficacy .green-banner::after {
  border-radius: 16px 19px 19px 6px;
  left: -10px;
}

.unresectable-efficacy .green-banner {
  border-radius: 0 0 50px 0px;
  margin-left: -20px !important;
}

.unresectable-efficacy #var-2.laurel-targ .green-banner {
  margin: 30px 0 35px 0;
  width: 89%;
          /*padding: 12px 5px 12px 35px;*/
  padding: 12px 5px 12px 38px;
}

.unresectable-efficacy #var-3.laurel-targ .green-banner {
  margin: 0px 0 30px 0;
  width: 86%;
  padding: 12px 0px 22px 52px;
}

#var-2.laurel-targ .green-banner p {
  font-size: 22px;
  line-height: 24px !important;
  font-weight: 500 !important;
  width: 103%;
  padding-bottom: 5px;
}

.unresectable-efficacy .footer-notes-tagisso {
  margin: 0 10px 7px 10px;
}

.unresectable-efficacy #pfss div.data-maturity.new-maturity div.footer-notes-tagisso {
  margin-left: 20px;
  margin-right: 20px;
}

.unresectable-efficacy .targisso-intro-container.vari-2 {
  margin: 50px 10px 10px;
}

.unresectable-efficacy .targisso-intro-container.vari-5 {
          /*margin: 80px 20px 10px;*/
  margin: 80px 15px 10px;
}

.unresectable-efficacy .targisso-intro-container.vari-3,
      .unresectable-efficacy .targisso-intro-container.vari-4,
      .unresectable-efficacy .targisso-intro-container.vari-6 {
  margin: 40px 20px 10px;
}

.unresectable-efficacy .column-1,
      .unresectable-efficacy .column-2,
      .unresectable-efficacy .column-3 {
  padding: 0px;
  width: 100%;
}

.unresectable-efficacy .column-2 img {
  position: relative;
  top: 0px;
}

.unresectable-efficacy .column-3 img {
  position: relative;
  top: 0px;
}
  
    /*.unresectable-efficacy .targisso-intro-container.vari-4 {*/
    /*  max-width: 318px;*/
    /*}*/
    
.unresectable-efficacy .targisso-intro-container .targisso-intro h2 {
  margin-bottom: 20px;
  /*padding-left: 4px;*/
  ;
}

.unresectable-efficacy #new-lesion-sites .targisso-intro-container .targisso-intro h2 {
  margin-bottom: 29px;
}

.unresectable-efficacy .cns-event .subhead {
  display: none;
}

.unresectable-efficacy .bar-tag-plac {
  max-width: 90%;
  margin: 0 auto;
}

.unresectable-efficacy .bar-tag-plac .cns-prerc-graph {
  text-align: center;
  display: block;
}

.unresectable-efficacy .startisifact-container .startisifact-content {
  flex-direction: column;
  justify-content: center;
  align-items: center;
      /*margin: 0 13px;*/
  margin: 0 15px;
  margin-bottom: 15px;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify {
  max-width: 100%;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify-crt {
  max-width: 100%;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify-placebo {
  max-width: 100%;
  margin-right: 0px;
  margin: 0;
      /*margin-left: 7px;*/
  ;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify, 
    .unresectable-efficacy .startisifact-container .startisifact-content .startisify-crt {
  border-right: 0;
  border-bottom: 2px solid #9B9B9B;
          /*margin-right: 0;*/
          /*margin-left: 0;*/
          /*border-right: 0;*/
          /*border-bottom: 2px solid #9B9B9B;*/
          /*max-width: 320px;*/
  max-width: 100%;
  padding: 0 14px;
  padding-right: 0;
  height: auto;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify {
  width: 100%;
          /*padding-left: 7px;*/
  padding: 0px 8px;
}

.unresectable-efficacy .startisifact-container .startisifact-content > div > ul > li,
   .unresectable-efficacy .startisifact-container .startisifact-content > div > p {
  font-size: 13px;
  line-height: 15px;
}

.unresectable-efficacy .startisifact-container .startisifact-content > div > ul > li {
  padding-bottom: 0px;
}

.unresectable-efficacy .startisifact-container .startisifact-content > div > ul {
  padding-left: 0px;
  list-style: none;
  padding-bottom: 0px;
  margin-bottom: 10px;
}

.unresectable-efficacy .startisifact-container .startisifact-content > div > h5 {
  margin: 0;
  text-indent: -10px;
  font: normal normal bold 13px / 15px 'Barlow';
  letter-spacing: 0px;
  color: #3B3C3E;
}

.unresectable-efficacy .chinese-site p {
  padding: 0 10px;
}

.unresectable-efficacy .tkt-container .tkt-content {
  align-items: center;
  flex-direction: column;
}

.unresectable-efficacy .egfr-chemor .footnotes.pill {
  text-align: center;
}

.unresectable-efficacy .mdt-molecular-container {
      /*margin: 0 20px;*/
  margin: 0 17px;
}

.unresectable-efficacy .mdt-molecular-container .mdt-molecular-content .data-maturity {
  padding: 0;
  margin: 0;
}

.unresectable-efficacy .foot-note-botttom.mobile-only {
  display: block;
}

.unresectable-efficacy .foot-note-botttom {
      /*display: none;*/
  margin: 0 15px;
}

.unresectable-efficacy .tagrisso-laura-trail-cta .visit-btn a {
  padding: 7px 70px;
}

.unresectable-efficacy .signi-stats-container-2 .signi-stats-2 .data-copy {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/mobile/Brain-and-Callout-mob.png) no-repeat;
  padding: 60px;
  background-size: 95%;
  background-position: top;
  padding-bottom: 45px;
}

.unresectable-efficacy .signi-stats-container-2 .signi-stats-2 .data-copy .copy-per p sup {
  font-size: 57%;
  top: -0.6em;
}

.unresectable-efficacy .signi-stats-container-2 .signi-stats-2 .data-copy .copy-content-2 .extrabold.copy-content-lg.surviva-txt {
  font-size: 22px;
  line-height: 22px;
}

.unresectable-efficacy #new-lesion-sites ul.bullet-list {
  margin-bottom: 0px;
      /*padding-left: 20px;*/
      /*padding-right: 20px;*/
  ;
}

.unresectable-efficacy .signi-stats-container-2 .signi-stats-2 .data-copy .copy-content-2 .ffb-med.vs-txt.vs-txt-new {
  line-height: 10px;
  font-size: 14px;
}

.unresectable-efficacy .signi-stats-container-2 .copy-content-sm {
  font-size: 14px;
  line-height: 16px;
  font-weight: 100;
}

.unresectable-efficacy .cns-event .cns-progression {
  text-align: center;
  font-size: 15px;
  font-weight: 600;
  margin-bottom: 0;
}

.unresectable-efficacy .signi-stats-container-2 .signi-stats-2 .data-copy .copy-per {
  background: none;
  max-width: 150px;
  padding: 0px;
  margin-left: 34px;
  text-align: center;
}

.unresectable-efficacy .signi-stats-container-2 .signi-stats-2 .data-copy .copy-per p {
  color: #FFFFFF;
  margin-top: -2px;
  font-size: 54px !important;
}

.unresectable-efficacy #new-lesion-sites {
  padding-bottom: 15px;
  padding-top: 40px;
  z-index: 1;
}

.unresectable-efficacy #new-lesion-sites .expand-img-mobile {
  margin-top: 10px;
}

.unresectable-efficacy #laura-study-design {
      /* margin-top: 70px; */
      padding-top: 0px;
      padding-bottom: 35px;
      z-index: 1;
      scroll-margin-top: -25px;
}

.unresectable-efficacy .targisso-intro-container.vari-4 {
  margin: 60px 15px 10px;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify-crt {
  border-right: 0;
  border-bottom: 2px solid #9B9B9B;
  max-width: 100%;
  padding: 0px 8px;
          /* padding: 0px 0px; */
  margin-left: 0px;
}

.unresectable-efficacy .egfrn-nslc img.mobile-only {
  width: 70%;
}

.unresectable-efficacy #laura-study-design .accordion.section {
      /*margin: 0 10px;*/
  margin: 0 20px 0 20px;
}

#tagrisso-approvals {
  margin-top: 30px;
  scroll-margin-top: -25px;
}

.unresectable-efficacy .column-head {
      /*color: #008995;*/
  font-size: 36px;
  padding: 0;
          margin-top: 13px;
}

.unresectable-efficacy p.footnotes.pill.new-pill {
  text-align: center;
  margin-top: -20px;
}

.unresectable-efficacy .efficacy-colum .column-2 .column-icon {
  margin-left: 22px;
}

.unresectable-efficacy .column-head2 {
  margin-top: 20px;
}

.unresectable-efficacy .column-head3 {
  margin-top: 20px;
}

.unresectable-efficacy #laura-study-design .egfr-chemor {
    /*margin-top: 30px;*/
    /*margin-bottom: 10px;*/
    /*margin: 30px 20px 10px 20px;*/
  margin: 30px 15px 10px 15px;
}

.unresectable-efficacy ul.bullet-list li:first-child {
        padding-bottom: 20px;
}

.unresectable-efficacy #pfss div.data-maturity.new-maturity ul.bullet-list-dash li {
  padding-left: 4px;
}

.unresectable-efficacy #laura-study-design.section-2 div.data-maturity.data-maturity3 ul.bullet-list li:first-child {
  margin-left: 5px;
}

.unresectable-efficacy ul.bullet-list li {
  padding-bottom: 15px;
}

.columnControl.section .column-2 {
      /* padding-left: 0; */
  padding-left: 10px;
  padding-right: 0px;
}

#pfss > div.page-section-inner.container > div:nth-child(6) > div > div {
  margin-bottom: 30px;
}

.visit-btn {
  max-width: 90%;
  margin-top: 25px;
}

.unresectable-efficacy #var-3.laurel-targ .green-banner {
  background: #008995;
  width: 89%;
  padding: 12px 5px 12px 42px;
}

.unresectable-efficacy .signi-stats-container .signi-stats .data-copy .copy-content .placebo {
  margin-bottom: 3px;
}

.unresectable-efficacy #laura-study-design .new-image .new-image-mobile {
  margin-left: 0;
}

.unresectable-efficacy #subgroups .panel-body {
  padding: 10px 5px 0px;
}

.unresectable-efficacy .green-banner {
        /*width: 75%;*/
        /*margin: 0px 0 35px 0;*/
        /*transform: none;*/
        /*padding: 12px 0px 22px 52px;*/
        /*transform: none;*/
  width: 80%;
  margin: 0px 0 35px 0;
  transform: none;
  padding: 12px 0px 22px 35px;
}

      /*animation for indication table*/
  
.unresectable-efficacy .indication-block-desktop-animation {
  display: flex;
  flex-direction: column;
  max-height: 100%;
  margin-top: 100px;
}

.indication-block-desktop-animation a:nth-child(2) {
  order: -1;
  max-width: 96%;
  top: -63px;
  margin: 0 auto;
}

.unresectable {
  top: 0px;
  min-width: 100%;
}

.unresectable-heading-block {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/mobile/Green%20Chevron%20Mobile.png) no-repeat;
  background-size: 100% 80%;
  min-height: 128px;
  position: absolute;
  min-width: 100%;
  top: -49px;
  margin: 0 auto;
  padding-top: 21px;
  margin-top: 0;
  left: 0;
}

p.unresectable-heading br {
  display: none;
}

.resectable, .unresectable, .locally-metastatic, .metastatic {
  text-align: center;
    /* padding: 6px; */
  width: 100%;
}

.resectable-heading-block {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/mobile/Green%20Chevron%20Outline%20Mobile.png) no-repeat;
  background-size: 100% 100%;
  min-height: 110px;
  margin-top: -49px;
  padding-top: 26px;
}

.indication-block-desktop-animation a:nth-child(3),
.indication-block-desktop-animation a:nth-child(4) {
  margin-top: 40px;
}

/*.indication-block-desktop-animation a:nth-child(3) .locally-metastatic-heading-block {*/
/*    background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/blue-arrow-shape.svg) no-repeat;*/
/*    background-size: 100% 100%;*/
/*    min-height: 109px;*/
/*    margin-top: -49px;*/
/*    padding-top: 14px;*/
/*}*/

.indication-block-desktop-animation a:nth-child(4) .metastatic-heading-block {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/mobile/Teal%20Chevron%20Outline%20Mobile.png) no-repeat;
  background-size: 100% 100%;
  min-height: 109px;
  margin-top: -49px;
  padding-top: 26px;
}

.indication-block-desktop-animation a:nth-child(3) .locally-metastatic-heading-block {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/mobile/Teal%20Chevron%20Outline%20Mobile.png) no-repeat;
  background-size: 100% 100%;
  min-height: 109px;
  margin-top: -49px;
  padding-top: 26px;
}

/*.indication-block-desktop-animation a:nth-child(4) .metastatic-heading-block {*/
/*    background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/blue-arrow-shape.svg) no-repeat;*/
/*    background-size: 100% 100%;*/
/*    min-height: 109px;*/
/*    margin-top: -49px;*/
/*    padding-top: 27px;*/
/*}*/

.unresectable-heading {
  font-size: 18px !important;
  line-height: 22px !important;
  margin-bottom: 0;
  font-weight: 800;
  max-width: 300px;
  margin: 0 auto;
}

.indication-block-desktop-animation a:nth-child(2) .unresectable-sub-heading {
  font-size: 21px;
  font-weight: 700;
  font-family: 'Barlow', 'sans-serif';
  padding-top: 47px;
}

.unresectable-sub-heading {
  border-bottom: 1.5px solid #9c879d;
}

.unresectable-indication-text {
  font-size: 15px;
  line-height: 19px !important;
  letter-spacing: -0.3px;
  font-weight: 400;
  padding-left: 20px;
  padding-right: 20px;
  margin-top: 16px;
  color: #FFFFFF;
  font-family: 'Barlow', 'sans-serif';
}

.resectable-heading,
.locally-metastatic-heading,
.metastatic-heading {
  font-size: 18px !important;
  line-height: 22px !important;
  margin-bottom: 0;
  font-weight: 800;
}

.resectable-sub-heading,
.locally-metastatic-sub-heading,
.indication-block-desktop-animation a:nth-child(4) .metastatic-sub-heading {
  font-size: 21px;
  font-weight: 800;
  font-family: 'Barlow', 'sans-serif';
}

.resectable-indication-text,
.locally-metastatic-indication-text,
.metastatic-indication-text {
  font-size: 15px;
  letter-spacing: -0.3px;
  line-height: 19px !important;
  padding: 0px 20px;
  margin-top: 16px;
}

.resectable-indication-text, 
.indication-block-desktop-animation a:nth-child(3) .locally-metastatic {
  margin-bottom: 20px;
}

.unresectable-efficacy .patients-with-egfr-block .patients-with-egfr-right p.text-center {
  margin-left: 13px;
}

.unresectable-efficacy .patients-with-egfr-block .patients-with-egfr-left p.text-center {
  margin-left: 0px;
}

/*animation for indication table*/

.unresectable-efficacy .indication-block-desktop-animation {
  display: flex;
  flex-direction: column;
  max-height: 100%;
  margin-top: 100px;
  margin: 100px auto;
}

.indication-block-desktop-animation a:nth-child(2) {
  order: -1;
  max-width: 96%;
  top: -63px;
  margin: 0 auto;
}

.unresectable {
  top: 0px;
  min-width: 100%;
}

.unresectable-heading-block {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/mobile/Green%20Chevron%20Mobile.png) no-repeat;
  background-size: 100% 80%;
  min-height: 128px;
  position: absolute;
  min-width: 100%;
  top: -49px;
  margin: 0 auto;
  padding-top: 21px;
  margin-top: 0;
  left: 0;
}

p.unresectable-heading br {
  display: none;
}

.resectable, .unresectable, .locally-metastatic, .metastatic {
  text-align: center;
  /* padding: 6px; */
  width: 100%;
}

.resectable-heading-block {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/mobile/Green%20Chevron%20Outline%20Mobile.png) no-repeat;
  background-size: 100% 100%;
  min-height: 110px;
  margin-top: -49px;
  padding-top: 26px;
}

.indication-block-desktop-animation a:nth-child(3),
.indication-block-desktop-animation a:nth-child(4) {
  margin-top: 40px;
}

/*.indication-block-desktop-animation a:nth-child(3) .locally-metastatic-heading-block {*/
/*    background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/blue-arrow-shape.svg) no-repeat;*/
/*    background-size: 100% 100%;*/
/*    min-height: 109px;*/
/*    margin-top: -49px;*/
/*    padding-top: 14px;*/
/*}*/

.indication-block-desktop-animation a:nth-child(4) .metastatic-heading-block {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/mobile/Teal%20Chevron%20Outline%20Mobile.png) no-repeat;
  background-size: 100% 100%;
  min-height: 109px;
  margin-top: -49px;
  padding-top: 26px;
}

.indication-block-desktop-animation a:nth-child(3) .locally-metastatic-heading-block {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/mobile/Teal%20Chevron%20Outline%20Mobile.png) no-repeat;
  background-size: 100% 100%;
  min-height: 109px;
  margin-top: -49px;
  padding-top: 26px;
}

/*.indication-block-desktop-animation a:nth-child(4) .metastatic-heading-block {*/
/*    background: url(/content/dam/open-digital/tagrisso-hcp/us/en/desktop/blue-arrow-shape.svg) no-repeat;*/
/*    background-size: 100% 100%;*/
/*    min-height: 109px;*/
/*    margin-top: -49px;*/
/*    padding-top: 27px;*/
/*}*/

.unresectable-heading {
  font-size: 18px !important;
  line-height: 22px !important;
  margin-bottom: 0;
  font-weight: 800;
  max-width: 300px;
  margin: 0 auto;
}

.indication-block-desktop-animation a:nth-child(2) .unresectable-sub-heading {
  font-size: 21px;
  font-weight: 700;
  font-family: 'Barlow', 'sans-serif';
  padding-top: 47px;
}

.unresectable-sub-heading {
  border-bottom: 1.5px solid #9c879d;
}

.unresectable-indication-text {
  font-size: 15px;
  line-height: 19px !important;
  letter-spacing: -0.3px;
  font-weight: 400;
  padding-left: 20px;
  padding-right: 20px;
  margin-top: 16px;
  color: #FFFFFF;
  font-family: 'Barlow', 'sans-serif';
}

.resectable-heading,
.locally-metastatic-heading,
.metastatic-heading {
  font-size: 18px !important;
  line-height: 22px !important;
  margin-bottom: 0;
  font-weight: 800;
}

.resectable-sub-heading,
.locally-metastatic-sub-heading,
.indication-block-desktop-animation a:nth-child(4) .metastatic-sub-heading {
  font-size: 21px;
  font-weight: 800;
  font-family: 'Barlow', 'sans-serif';
}

.resectable-indication-text,
.locally-metastatic-indication-text,
.metastatic-indication-text {
  font-size: 15px;
  letter-spacing: -0.3px;
  line-height: 19px !important;
  padding: 0px 20px;
  margin-top: 16px;
}

.resectable-indication-text, 
.indication-block-desktop-animation a:nth-child(3) .locally-metastatic {
  margin-bottom: 20px;
}

.unresectable-efficacy .patients-with-egfr-block .patients-with-egfr-right p.text-center {
  margin-left: 13px;
}

.unresectable-efficacy .patients-with-egfr-block .patients-with-egfr-left p.text-center {
  margin-left: 0px;
}

/*animation for indication table*/
      
}

@media screen and (min-width:992px) {
      
      @  keyframes scale-up {
    from {
              background-size: 125% auto;
  }

  to {
    background-size: 200% auto;
  }
}

.dom-ready .banner-bg-section:after {
      /*background-size: 200% auto;*/
      /*background-position: center;*/
      /*background-position-x: center;*/
      /*transform: scale(1.5);*/
    transition: 4s ease;
}

.unresectable-efficacy ul.bullet-list {
  margin-bottom: 0px;
  margin-left: 0px !important;
}

.slide-frm-left, .slide-frm-right {
  position: relative;
  opacity: 0;
}

.slide-frm-left {
  transform: translate(-20vw);
}

.slide-frm-right {
  transform: translate(20vw);
}
  }



@media only screen and (min-width: 320px) and (max-width: 374px) {
  .top-header {
    padding: 0;
  }

  .unresectable-efficacy .green-banner.is-visible .callout sup {
    line-height: 33px;
 /*newly added (20-11-24)*/
    font-size: 15px;
  }

  .unresectable-efficacy .green-banner {
    width: 75%;
  }
}

@media only screen and (min-width: 320px) and (max-width: 852px) {
  .unresectable-efficacy .indication-block-desktop-animation {
    margin-left: 15px;
    margin-right: 15px;
    margin-bottom: 35px;
  }
}

@media only screen and (min-width: 768px) and (max-width: 1024px) {
      @  keyframes scale-up {
    from {
              background-size: 125% auto;
  }

  to {
    background-size: 200% auto;
    background-position-y: -14px;
  }
}

.dom-ready .banner-bg-section:after {
  animation: 1.5s linear forwards scale-up;
}

.unresectable-efficacy #laura-study-design .accordion.section {
  margin: 0 10px;
  max-width: 100%;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify-crt {
  width: 100%;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify-placebo {
  width: 100%;
}

.unresectable-efficacy .signi-stats-container {
  max-width: 95%;
}

.unresectable-efficacy .accordion.section {
  max-width: 93%;
}

.accordion.section .accordion-container {
  width: 100%;
}
  }

@media only screen and (min-width: 753px) and (max-width: 1037px) {
      @  keyframes scale-upm {
    from {
              background-size: 125% auto;
              /*background-position-y: 16px;*/
    ;
  }

  to {
    background-size: 200% auto;
              /*transform: scale(2);*/
              /*background-position-y: -14px;*/
    ;
  }
}

.dom-ready .banner-bg-section:after {
          /*animation: 2.5s linear forwards scale-upm;*/
  ;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify-crt {
  width: 100%;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify-placebo {
  width: 100%;
}

.unresectable-efficacy .signi-stats-container {
  max-width: 95%;
}

.unresectable-efficacy .accordion.section {
  max-width: 93%;
}

.accordion.section .accordion-container {
  width: 100%;
}

.banner-bg-section:after {
  background-position: center 75%;
 /*newly added (20-11-24)*/
  ;
}

.unresectable-efficacy .banner-bg-section:after {
  background-position-y: -20px;
}
  }

@media only screen and (min-width: 418px) and (max-width: 480px) {
  .unresectable-efficacy #pfss img.new-indication {
    left: -10%;
  }
}

@media only screen and (min-width: 418px) and (max-width: 565px) {
  .unresectable-efficacy #pfss .targisso-intro-container .targisso-intro {
        /* margin-top: -107px; */
    margin-top: 162px;
  }

  .unresectable-efficacy #pfss img.new-indication {
    top: 28px;
  }

  .unresectable-efficacy #pfss img.new-indication {
        /* width: 100%; */
        /* left: -10px; */
        /* height: auto; */
    width: 100%;
        /*left: 0px;*/
    height: auto;
    top: 38px;
  }
}

@media screen and (min-width: 481px) and (max-width: 600px) {
  .unresectable-efficacy #pfss img.new-indication {
    left: -15%;
  }
}

@media screen and (min-width: 601px) and (max-width: 819px) {
  .unresectable-efficacy #pfss img.new-indication {
    left: -25%;
  }
}

@media only screen and (min-width: 991px) {
  .unresectable-efficacy #pfss img.new-indication {
    width: 200px;
    left: -13%;
    top: -31px;
  }
}

@media only screen and (max-device-width:752px) {
      /*@keyframes scale-upm {*/
      /*      from {*/
      /*        background-size: 125% auto;*/
              /*background-position-y: 16px;*/
      /*      }*/
      /*      to {*/
      /*        background-size: 180% auto;*/
              /*transform: scale(2);*/
              /*background-position-y: -14px;*/
      /*      }*/
      /*    }*/
      @  keyframes scale-upm {
    from {
              /*background-size: 125% auto;*/
              /*background-position-y: 16px;*/
              transform: none;
  }

  to {
              /*background-size: 380% auto;*/
    transform: scale(1.5);
              /*background-position-y: -14px;*/
    ;
  }
}

.dom-ready .banner-bg-section:after {
  animation: 2.5s linear forwards scale-upm;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify-crt {
  width: 100%;
}

.unresectable-efficacy .startisifact-container .startisifact-content .startisify-placebo {
  width: 100%;
}

.unresectable-efficacy .signi-stats-container {
  max-width: 99%;
}

.unresectable-efficacy .accordion.section {
  max-width: 93%;
}

.accordion.section .accordion-container {
  width: 100%;
}
  }

@media only screen and (min-width:890px) and (max-width: 990px) {
  .unresectable-efficacy .banner-bg-section:after {
    background-position-y: -24px;
  }

  .unresectable-efficacy #pfss img.new-indication {
    left: -29%;
  }
}

@media only screen and (min-width:990px) and (max-width: 1037px) {
  .unresectable-efficacy .banner-bg-section:after {
    background-position-y: -6px;
  }

  .unresectable-efficacy #pfss img.new-indication {
    left: -29%;
  }

  .unresectable-efficacy img.new-indication {
    transform: translate(4%);
  }
}

@media only screen and (min-device-width: 820px) and (max-device-width: 1106px) and (orientation:portrait) {
  .unresectable-efficacy #pfss img.new-indication {
    width: 80%;
          /*left: -77px;*/
    left: -31%;
    height: auto;
    top: 180px;
  }

  .unresectable-efficacy .targisso-intro-container {
    padding-top: 20px;
  }

  .unresectable-efficacy .banner-bg-section:after {
    background-position-y: -22px;
  }

  .dom-ready .banner-bg-section:after {
    transform: scale(1.4);
  }
}

@media only screen and (min-width: 820px) and (max-width: 1106px) {
  .unresectable-efficacy #pfss img.new-indication {
    left: -31%;
  }
}

@media only screen and (min-device-width: 820px) and (max-device-width: 1106px) and (orientation:landscape) {
  .unresectable-efficacy .indication-block-desktop-animation {
    min-height: 350px;
  }
}

@media screen and (min-width: 992px) {
  .unresectable-efficacy #pfss img.new-indication {
    width: 200px;
    left: -13%;
    top: -31px;
  }

  .unresectable-efficacy #ttdm, .unresectable-efficacy #interim-os {
    padding-bottom: 70px;
  }

  .unresectable-efficacy #interim-os {
    padding-top: 50px;
  }
   #ttdm {
        padding-top: 60px;
    }
    
    
    .unresectable-efficacy.laura-nsclc .polygon p {
    padding:0px 10px
}
}

@media only screen and (min-width: 992px) and (max-width: 1300px) {
  .unresectable-efficacy .green-banner {
             /*transform: translateX(-47%); */
    transform: translateX(-78%);
  }
}

@media screen and (min-width: 1000px) and (max-width: 1200px) {
  .laura-rad-oncologists #tagrisso-approvals img.new-indication {
        /* width: auto; */
        /* left: 48%; */
        /* height: 138px; */
    width: 120px;
    left: 75%;
    top: 0%;
  }
}
/*@media screen and (min-width: 1600px) {*/
/*    .unresectable-efficacy .indication-block-desktop-animation{*/
/*        max-height: 387px;*/
/*    }*/
/*}*/

@media screen and (min-width: 1600px) {
      @  keyframes scale-up {
    from {
              background-size: 100% auto;
  }

  to {
    background-size: 105% auto;
  }
}

.dom-ready .banner-bg-section:after {
  animation: 1.5s linear forwards scale-up;
}
  }

@media only screen and (min-width:2560px) {
      
      @  keyframes scale-up {
    from {
              background-size: 100% auto;
  }

  to {
    background-size: 125% auto;
  }
}

.dom-ready .banner-bg-section:after {
  animation: 1.5s linear forwards scale-up;
}
}

@media not all and (min-resolution:.001dpcm) {
 
    @  supports (-webkit-appearance:none) and (stroke-color:transparent) {
        /*.unresectable-efficacy .component-section .page-section-inner {*/
        /*    position: relative;*/
        /*    z-index: 1;*/
        /*}*/
    ;
  }
}

.footer-notes-tagisso.new-small-note .footnotes {
  margin-left: -3px !important;
}

@media screen and (max-width: 375px) {

  div#accordion-horizontal1281466663 {
    margin-left: 8px;
  }
}

p.cns-subtext {
  text-wrap: nowrap;
  margin-top: 20px;
}

.callout-mbo {
  display: none;
}
@media screen and (max-width: 400px) {
    .unresectable-efficacy #var-3.laurel-targ .green-banner{
                width: 94%;
    }
    .unresectable-efficacy .targisso-intro-container .targisso-intro h2{
            max-width: 340px;
    }
}
@media only screen and (min-width: 320px) and (max-width: 341px) {
  .unresectable-efficacy #pfss img.new-indication {
    left: 0;
  }
      .unresectable-efficacy #var-3.laurel-targ .green-banner {
        width: 89%;
    }
}
@media screen and (max-width: 991px) {
  p.cns-subtext {
    /*display: none;*/
    text-wrap: wrap;
    text-align: left;
    padding: 0 8px;
  }
 .unresectable-efficacy .copy-right.footnotes {
        max-width: 180px;
        margin: 5px auto;
    }
   .unresectable-efficacy .footer-content {
        padding: 0 79px;
    }


  .unresectable-efficacy #ttdm .eyebrow {
    padding-right: 18px;
    padding-left: 18px;
  }
  
  


  .unresectable-efficacy  #interim-os .eyebrow {
    padding-right: 18px;
    padding-left: 18px;
  }
  
   #interim-os .callout-mbo {
     margin-bottom: 25px;
  }

  .callout-mbo {
    display: block;
    width: 50%;
    margin: 10px auto;
  }

  .callout-mbo img {
    width: 100%;
  }
  
  #interim-os .expand-img-mobile{
      margin-top:10px;
  }
/*  .unresectable-efficacy #ttdm*/
/*    {*/
/*    padding: 40px 0;*/
/*    z-index: 1;*/
/*}*/
  .unresectable-efficacy  #ttdm,
    .unresectable-efficacy  #interim-os {
    padding: 40px 0;
    z-index: 1;
}
}
.center-align {
    text-align: center;
}