/* ------------------------ chemotheraphy Safety page styling  -  body tag tagChemoSafety*/

.metastatic-safety .metastatic-safety-ref {
  display: none;
}
.metastatic-nsclc.metastatic-safety .bg-fff{
   background: #fff; 
}

.metastatic-nsclc.metastatic-safety .customTable td:nth-child(1) {
  width: 30%;
}

.tagChemoSafety h1.meta-safety-head-1 {
  margin: 0px 0 25px 0 !important;
}

.tagChemoSafety p.eyebrow.meta-safety-eyebrow-1 {
  padding: 0px 0 10px 0;
}

.tagChemoSafety p.subhead.meta-safety-subhead-1 {
  margin: 25px 0 20px 0 !important;
  margin-bottom: 10px !important;
}

.bullet-list.with-image .flex {
  display: flex;
  align-items: center;
  gap: 9px;
}

.bullet-list.with-image .flex img.icon {
  max-width: 75px;
}
#table-footnote > div.page-section-inner.container > div:nth-child(2) > div > div > ul > div.second.flex > img{
  max-width: 80px;
}
#table-footnote > div.page-section-inner.container > div:nth-child(2) > div > div > ul > div.second.flex{
  gap: 5px;
}
ul.bullet-list.with-image li:before {
  content: "";
}



/* median exposure vertical graph bars */

.tagChemoSafety .chemo-safety-median-2  p.subhead.meta-safety-subhead-1 {
  margin: 20px 0 40px 0 !important;
}

.tagChemoSafety .chemo-safety-median-2  .chart-duration.chart-duration-tagrisso {
  color: #4a235a;
  white-space: nowrap;
  line-height: 18px;
}

.tagChemoSafety .chemo-safety-median-2  .chart-detail.chart-detail-tagrisso {
  color: #4a235a;
  white-space: nowrap;
  display: block;
 /* margin-top: 5px; */
  ;
}

.tagChemoSafety .chemo-safety-median-2.chart-container {
  font-family: 'Barlow';
  width: 100%;
  border: 2px solid #0000004D;
  border-radius: 13px;
  padding: 5px 10px 10px;
  margin: 20px auto;
  margin-top: 38px;
  /*border: 2px solid #AFB0B3;*/
}

#adverse-reactions > div.page-section-inner.container > div:nth-child(3) > div > ul > li:nth-child(1) > ul > li {
  padding: 0;
}

.tagChemoSafety ul.bullet-list.dose-red.after-ar-table li {
  padding-top: 10px;
  padding-bottom: 5px;
}

.tagChemoSafety ul.bullet-list.dose-red.after-ar-table li::before {
  top: auto;
}

.tagChemoSafety table.customTable.lab-table.ar-table-wrapper {
  margin-bottom: 40px !important;
  max-width: 680px;
}

.tagChemoSafety p.eyebrow.meta-safety-eyebrow-2 {
  margin-top: 66px;
  margin-bottom: -15px;
}

.tagChemoSafety h1.meta-safety-head-2 {
  margin-bottom: 0px !important;
}

.tagChemoSafety .meta-safety-head-2 {
  margin-bottom: 22px !important;
}

.tagChemoSafety .chemo-safety-median-2  .chart-row {
  display: flex;
  align-items: center;
  margin-bottom: 10px;
}

.tagChemoSafety .chemo-safety-median-2  .chart-bar {
  display: flex;
  align-items: center;
  height: 23px;
  background-color: #5B305D;
  position: relative;
}

.tagChemoSafety .chemo-safety-median-2  .chart-bar.chart-bar-tagrisso {
  width: 609px;
  clip-path: polygon(
    0 0,
    99% 0,
    100% 50%,
    99% 100%,
    0 100%
  );
}

.tagChemoSafety .chemo-safety-median-2  .chart-bar.subtle-color {
  background-color: #96999C;
}

.tagChemoSafety .chemo-safety-median-2  .chart-bar.chart-bar-platinum.subtle-color {
  width: 57px;
  clip-path: polygon(0 0, 92% 0, 101% 50%, 92% 100%, 0 100%);
}

.tagChemoSafety .chemo-safety-median-2  .chart-bar.chart-bar-pemetrexed.subtle-color {
  width: 167px;
  clip-path: polygon(0 0, 96% 0, 100% 50%, 96% 100%, 0 100%);
}

.tagChemoSafety .chemo-safety-median-2  .chart-bar::after {
  /* content: ''; */
  position: absolute;
  right: -7px;
  top: 0;
  width: 0;
  height: 0px;
  border-top: 22.5px solid transparent;
  border-left: 8px solid #5B305D;
  border-bottom: 22.5px solid transparent;
}

.tagChemoSafety .chemo-safety-median-2  .chart-bar.subtle-color::after {
  border-left-color: #96999C;
}

.tagChemoSafety .chemo-safety-median-2  .chart-label {
  font-size: 16px;
  line-height: 14.67px;
  /* font-weight: 600; */
  color: #333333;
  /* padding-left: 10px; */
  letter-spacing: -0.09px;
}

.tagChemoSafety .chemo-safety-median-2  .chart-duration {
  font-size: 15px;
  font-weight: bold;
  color: #4a235a;
  margin-left: 18px;
  margin-top: 2px;
}

.tagChemoSafety .chemo-safety-median-2  .chart-detail {
  font-size: 13px;
  color: #4a235a;
  margin-left: 5px;
}

.tagChemoSafety .chemo-safety-median-2  span.chart-months-number {
  font-size: 28px;
}

.tagChemoSafety .chemo-safety-median-2  .chart-row.chart-bar-tagrisso {
  /*margin-bottom: 0;*/
  ;
}

.tagChemoSafety .chemo-safety-median-2  .chart-duration.chart-duration-platinum {
  color: #333333;
  line-height: 18px;
}

.tagChemoSafety .chemo-safety-median-2  .chart-detail.chart-detail-platinum {
  color: #333333;
  font-size: 14px;
}

.tagChemoSafety .chemo-safety-median-2  .chart-duration.chart-duration-pemetrexed {
  color: #7B597D;
}

.tagChemoSafety .chemo-safety-median-2  .chart-detail.chart-detail-pemetrexed {
  color: #7B597D;
}

.tagChemoSafety .chemo-safety-median-2  .chart-detail.chart-detail-pemetrexed {
  margin-top: 11px;
}

.tagChemoSafety .chemo-safety-median-2  .chart-detail.chart-detail-platinum {
  font-weight: 400;
  margin-left: 0px;
}

.tagChemoSafety .chemo-safety-median-2   span.chart-detail.chart-detail-tagrisso {
  font-weight: 400;
  margin-left: 0px;
  font-size: 13.5px;
}

.tagChemoSafety .chemo-safety-median-2  .chart-title {
  text-align: center;
  font-size: 22px;
  color: #008995;
  padding: 0px 5px;
  position: relative;
  z-index: 1;
  font-weight: 600;
  bottom: 45px;
  width: 83%;
  left: 10%;
  margin-bottom: -20px;
  line-height: 26px;
  background: #ffff;
}

.tagChemoSafety .chemo-safety-median-1.chart-container {
  font-family: 'Barlow';
  width: 100%;
  border: 2px solid #0000004D;
  border-radius: 13px;
  padding: 5px 10px 25px;
  margin: 40px auto;
}

.tagChemoSafety .chemo-safety-median-1 .chart-row {
  display: flex;
  align-items: center;
  margin-bottom: 20px;
}

.tagChemoSafety .chemo-safety-median-1 .chart-bar {
  display: flex;
  align-items: center;
  height: 23px;
  background-color: #5B305D;
  position: relative;
  width: 424px;
  border-right: 1px solid #5B305D;
  clip-path: polygon(0 0, 98% 0, 100% 50%, 98% 100%, 0 100%);
}

.tagChemoSafety .chemo-safety-median-1 .chart-bar::after {
  /* content: ''; */
  position: absolute;
  right: -8.9px;
  top: 0px;
  width: 0;
  height: 0px;
  border-top: 22.2px solid transparent;
  border-left: 8px solid #5B305D;
  border-bottom: 22.2px solid transparent;
}

.tagChemoSafety .chemo-safety-median-1 .chart-label {
  font-size: 16px;
  line-height: 14.67px;
  font-weight: bold;
  color: #5B305D;
  /* padding-left: 10px; */
  letter-spacing: -0.09px;
}

.tagChemoSafety .chemo-safety-median-1 .chart-duration {
  font-size: 14px;
  font-weight: bold;
  color: #4a235a;
  margin-left: 20px;
  margin-top: 2px;
}

.tagChemoSafety .chemo-safety-median-1 .chart-detail {
  font-size: 14px;
  color: #4a235a;
  margin-left: 5px;
}

.tagChemoSafety .chemo-safety-median-1 span.chart-months-number {
  font-size: 30px;
}

.tagChemoSafety .chemo-safety-median-1 .chart-duration.chart-duration-tagrisso {
  color: #4a235a;
  white-space: normal;
  line-height: 12px;
  font-size: 15px;
}

.tagChemoSafety .chemo-safety-median-1 .chart-detail.chart-detail-tagrisso {
  color: #4a235a;
  white-space: nowrap;
  display: block;
 /* margin-top: 10px;*/
  font-weight: normal;
}

.tagChemoSafety .chemo-safety-median-1 .chart-bar-tagrisso {
  margin-bottom: 0;
}

.tagChemoSafety .chemo-safety-median-1 .chart-duration.chart-duration-platinum {
  color: #7B597D;
}

.tagChemoSafety .chemo-safety-median-1 .chart-detail.chart-detail-platinum {
  color: #7B597D;
  font-size: 14px;
}

.tagChemoSafety .chemo-safety-median-1  .chart-title {
  text-align: center;
  font-size: 22px;
  color: #008995;
  padding: 0px 5px;
  position: relative;
  z-index: 1;
  font-weight: 600;
  bottom: 45px;
  width: fit-content;
  left: 20%;
  background: none;
  margin-bottom: -25px;
  background: #fff;
}

/* bars graph end */

.tagChemoSafety  .ae-chart-wrapper img {
  width: 95%;
  padding: 20px 0px;
}

.tagChemoSafety  .ae-chart-wrapper img {
  width: 95%;
  padding: 0;
}

.tagChemoSafety  p.eyebrow.meta-safety-eyebrow-1.after-ae-table {
  padding: 40px 0 5px 0;
}

.tagChemoSafety  .ae-chart-title {
  font-size: 15px;
  font-weight: 600;
  line-height: 19px;
  text-align: center;
  color: #333333;
  padding: 15px 0px 0px 0px;
  margin-bottom: -20px;
  position: relative;
  top: 20px;
  font-family: 'Barlow';
}

.tagChemoSafety .ar-table-wrapper td {
  line-height: 18px;
}

.tagChemoSafety .ar-table-wrapper tr.grey-row {
  background: #F1F1F1;
}

.tagChemoSafety .ar-table-wrapper tr.span1 th:nth-child(1) {
  text-align: left;
  position: relative;
  top: 10px;
  width: 45%;
}

.tagChemoSafety .ar-table-wrapper tr.span1 th:nth-child(2), .ar-table-wrapper tr.span1 th:nth-child(3) {
  line-height: 19px !important;
}

.tagChemoSafety p.tab-title.ffb-sb.chart-head.head-wrap.ar-table-title {
  margin: 0;
  position: relative;
  top: 10px;
}

.tagChemoSafety p.footnotes.chart-footnote.text-left.after-adverse-table {
  margin-bottom: 20px;
}

#adverse-reactions > div.page-section-inner.container > div:nth-child(3) > div > p {
  margin-top: 30px;
}

.tagChemoSafety ul.bullet-list.dose-red.after-ar-table {
  /* margin-top: 30px; */
  margin-bottom: 30px;
}

.tagChemoSafety ul.bullet-list.dose-red.after-ar-table-2 {
  margin-bottom: 30px;
}

.tagChemoSafety p.footnotes.after-ar-table-2a {
  margin-bottom: 40px;
  margin-top: 15px;
}

.tagChemoSafety p.subhead.meta-safety-subhead-1.after-ae-table {
  padding-bottom: 0;
}

.tagChemoSafety .chart-container.chemo-safety-median-1 {
  margin-bottom: 15px !important;
  padding-bottom: 20px;
}

.tagChemoSafety ul.bullet-list.dose-red.after-median-table {
  margin-top: 30px;
  margin-bottom: 20px;
  margin-left: 9px !important;
}
.tagChemoSafety ul.bullet-list.dose-red.after-median-table li:first-child{
  margin-bottom: 15px;
}
.tagChemoSafety p.footnotes.after-median-table-2a {
  padding-bottom: 80px;
}

.tagChemoSafety h2.slide-to-top.first-line-tag.after-manage-cta.is-visible {
  margin-top: 10px;
  margin-bottom: 40px;
}

.tagChemoSafety p.eyebrow.after-manage-cta {
  padding-top: 40px;
}

.tagChemoSafety .chemo-safety-median-1.chart-container::before {
  content: "";
  display: inline-block;
  width: 61%;
  height: 2px;
  background-color: #ffffff;
  position: relative;
  top: -22px;
  left: 143px;
}

.tagChemoSafety .chemo-safety-median-2.chart-container::before {
  content: "";
  display: inline-block;
  width: 80%;
  height: 2px;
  background-color: #ffffff;
  position: relative;
  top: -22px;
  left: 80px;
}

.tagChemoSafety #laboratory-abnormalities .customTable.lab-table tr th {
  font: normal normal bold 17px/19px 'Barlow' !important;
}

.tagChemoSafety #laboratory-abnormalities .customTable.lab-table tr th:last-child {
  font: normal normal 500 17px/19px 'Barlow' !important;
  color: #5B305D;
      padding: 4px 0 4px 8px;
}

.tagChemoSafety #laboratory-abnormalities .customTable.lab-table tr td.chart-body.ffb-med.purple-txt {
  color: #5B305D;
}

.tagChemoSafety #laboratory-abnormalities .customTable.lab-table tr.span1 th:nth-child(4) {
  color: #5B305D;
  font: normal normal 500 17px/19px 'Barlow' !important;
}

@media screen and (max-width:768px) {
    
    
  .ar-table-wrapper .chart-body.ffb-med {
    line-height: 18px !important;
  }

  .tagChemoSafety .ae-chart-title {
    margin-bottom: 25px;
  }

  .tagChemoSafety .ar-table-wrapper tr.span1 th:nth-child(1) {
    text-align: left;
    position: relative;
    top: 0px;
  }

  .tagChemoSafety .chemo-safety-median-1 .chart-bar {
    height: 32px;
    min-width: 155px;
    width: 155px;
  }

  .tagChemoSafety .chemo-safety-median-1 .chart-bar::after {
    right: -13px;
    border-top: 33px solid transparent;
    border-left: 13px solid #5B305D;
    border-bottom: 33px solid transparent;
  }

  .tagChemoSafety .chemo-safety-median-1 span.chart-months-number {
    font-size: 25px;
  }

  .tagChemoSafety .chemo-safety-median-1 .chart-detail.chart-detail-tagrisso {
    margin: 0;
  }

  .tagChemoSafety .chemo-safety-median-2  .chart-bar {
    display: flex;
    align-items: center;
    height: 32px;
    background-color: #5B305D;
    position: relative;
  }

  .tagChemoSafety .chemo-safety-median-2  .chart-bar::after {
    content: '';
    position: absolute;
    right: -13px;
    top: 0;
    width: 0;
    height: 0px;
    border-top: 33px solid transparent;
    border-left: 13px solid #5B305D;
    border-bottom: 33px solid transparent;
    margin-right: 0.5px;
  }

  .tagChemoSafety .chemo-safety-median-2  .chart-row {
    display: flex;
    align-items: center;
    margin-bottom: 17px;
  }

  .tagChemoSafety .chemo-safety-median-1 .chart-duration.chart-duration-tagrisso {
    line-height: 16px;
  }

  .tagChemoSafety .chemo-safety-median-2  .chart-duration.chart-duration-tagrisso {
    color: #4a235a;
    line-height: 12px;
    font-size: 15px;
    white-space: normal;
    margin-left: -13px;
    position: relative;
    left: 31px;
    top: 1px;
  }

  .tagChemoSafety .chemo-safety-median-2 .chart-duration.chart-duration-pemetrexed {
    color: #7B597D;
    font-size: 15px;
    white-space: nowrap;
    position: relative;
    top: -57px;
    display: block;
    left: 145px;
    margin: 0;
    width: 50px;
  }

  .tagChemoSafety .chemo-safety-median-2 .chart-detail.chart-detail-platinum {
    font-size: 12px;
  }

  .tagChemoSafety .chemo-safety-median-2 .chart-duration.chart-duration-platinum {
    line-height: 14px;
  }

  .tagChemoSafety .chemo-safety-median-2  .chart-bar.chart-bar-pemetrexed.subtle-color {
    width: 61px !important;
    /* min-width: 61px; */
    height: 32px;
    clip-path: polygon(0 0, 93% 0, 100% 50%, 93% 100%, 0 100%);
  }

  .tagChemoSafety .chemo-safety-median-2  .chart-detail.chart-detail-pemetrexed {
    line-height: 12px;
    margin: 0;
    position: relative;
    left: 147px;
    top: -58px;
    display: block;
    width: 120px;
  }

  .tagChemoSafety .chemo-safety-median-2  .chart-bar.chart-bar-platinum.subtle-color {
    width: 21px;
    height: 32px;
    min-width: 21px;
    clip-path: polygon(0 0, 85% 0, 100% 50%, 87% 100%, 0 100%);
  }

  .tagChemoSafety .chemo-safety-median-2   span.chart-detail.chart-detail-tagrisso {
    white-space: initial;
    display: block;
    font-size: 12px;
    line-height: 12px;
    margin: 0;
    font-weight: 400;
    width: 60%;
    margin-top: 1px;
  }

  .tagChemoSafety .chemo-safety-median-2 .chart-bar.chart-bar-tagrisso {
    width: 223px;
    min-width: 214px;
    clip-path: polygon(0 0, 98% 0, 100% 50%, 98% 100%, 0 100%);
  }

  .tagChemoSafety .chemo-safety-median-1  .chart-title {
    text-align: center;
    font-size: 22px;
    color: #008995;
    padding: 0px 5px;
    position: relative;
    z-index: 1;
    font-weight: 600;
    bottom: 53px;
    width: 80%;
    left: 10%;
    margin-bottom: -60px;
    bottom: 70px;
    background: none;
  }

  .tagChemoSafety .chemo-safety-median-2  .chart-title {
    text-align: center;
    font-size: 22px;
    color: #008995;
    position: relative;
    z-index: 1;
    font-weight: 600;
    bottom: 68px;
    width: 76%;
    left: 12%;
    padding: 0;
    margin-bottom: -50px;
  }

  .tagChemoSafety .chemo-safety-median-1.chart-container {
    font-family: 'Barlow';
    width: 100%;
    border: 1px solid #0000004D;
    border-radius: 13px;
    padding: 13px 10px 30px;
    margin: 60px 0 auto;
  }
.chemo-safety-median-2 .chart-label-tagrisso{
  padding-bottom: 6px;
}
  .chemo-safety-median-1 .chart-label-tagrisso{
  padding-bottom: 6px;
    font-size:13px!important
}
  .tagChemoSafety .chemo-safety-median-2.chart-container {
    font-family: 'Barlow';
    width: 100%;
    border: 1px solid #0000004D;
    border-radius: 13px;
    padding: 5px 10px 15px;
    margin: 70px 0 25px 0;
  }

  .tagChemoSafety ul.bullet-list.dose-red.after-median-table {
    margin-top: 20px !important;
  }

  .tagChemoSafety  p.footnotes.after-median-table-2a {
    margin-top: -10px;
    margin-bottom: -20px;
  }

  .tagChemoSafety p.eyebrow.meta-safety-eyebrow-1 {
    padding: 0px 0 15px 0;
  }

  .tagChemoSafety p.subhead.meta-safety-subhead-1 {
    margin: 20px 0 10px 0 !important;
  }

  .tagChemoSafety p.footnotes.chart-footnote.text-left.after-adverse-table {
    margin-bottom: 30px;
  }

  .tagChemoSafety table.customTable.lab-table.ar-table-wrapper {
    margin-bottom: -10px !important;
  }

  .tagChemoSafety  .primary-btn-wrap.safety-link.metastatic-safety--link.chemo-btn {
    margin-top: -10px;
  }

  .tagChemoSafety ul.bullet-list.dose-red.after-ar-table-2 {
    margin-bottom: 30px;
    margin-top: 40px !important;
  }

  .tagChemoSafety p.eyebrow.meta-safety-eyebrow-2 {
    margin-top: 40px;
    margin-bottom: -20px;
  }

  .tagChemoSafety  p.eyebrow.meta-safety-eyebrow-1.after-ae-table {
 /* padding: 20px 0 5px 0;*/
    padding: 60px 0 5px 0;
  }

  .tagChemoSafety .chemo-safety-median-2.chart-container::before {
    content: "";
    display: inline-block;
    width: 56%;
    height: 10px;
    background-color: #ffffff;
    position: relative;
    top: -19px;
    left: 46px;
  }

  .tagChemoSafety .chemo-safety-median-1.chart-container::before {
    content: "";
    display: inline-block;
    width: 80%;
    height: 10px;
    background-color: #ffffff;
    position: relative;
    top: -22px;
    left: 31px;
  }
}


  
/* ------------------------ chemotheraphy Safety page styling   END */

/* Resectable safety page styling */
.borderbtm0 td {
  border-bottom: 0 none;
}

.bordertop0 td {
  border-top: 0 none;
}

.resectable-nsclc.safety .section-1 h1 {
  margin: 35px 0 30px 0;
}

.ml-2 {
  margin-left: 2px;
}
/*.isi-wrapper.open{
  margin-top:60px;
}*/
.resectable-nsclc.safety .section-1 .subhead {
  margin: 0 0 40px 0;
}

.resectable-nsclc.safety .text-s-1 {
  font-size: 21px;
}

.resectable-nsclc.safety .section-1 .last-footnote {
  margin: 0 0 35px 0;
}

.resectable-nsclc.safety .section-1 .chart-footer {
  margin: 20px 0 35px 35px;
  text-indent: 0;
}

.footer .html-asset-inner .fa-spinner {
  display: none;
}

.footer .htmlAsset.section {
  visibility: hidden;
  max-height: 0;
}

.white_bg {
  padding-bottom: 0px;
}

.resectable-nsclc.safety .section-1 .chart-head3 {
/* padding-left: 23px !important;*/
  line-height: 20px !important;
  padding-top: 30px;
  letter-spacing: -0.32px;
}

.resectable-nsclc.safety .section-1 .customTable td:nth-child(1) {
/*padding-left: 22px !important;*/
  font-size: 18px;
  padding-bottom: 6px!important;
}

.resectable-nsclc.safety .section-1  .span4 {
  border-bottom: 1px solid transparent !important;
}

.resectable-nsclc.safety .section-1 .subhead2 {
  margin: 58px 0 25px 0 !important;
}

.resectable-nsclc.safety .section-1 .bullet-list li {
  margin: 0px 0 0px 0;
}

.resectable-nsclc.safety .section-2 h2 {
  margin: 55px 0 45px 0;
}

.section-2 .span4 {
  background-color: #fff;
  border: 1px solid #fff;
}

.resectable-nsclc.safety .section-2 .customTable {
  margin: 20px auto 45px auto !important;
}

.resectable-nsclc.safety .section-2  .chart-below-copy {
  margin: 0 0 30px 0;
}

.resectable-nsclc.safety .section-2 .last-footnote {
  margin: 0 0 35px 0;
}

.text.parbase ul.dose-red {
  margin-bottom: 58px;
}

/* .safety-table--two tr:not(.borderbtm0) {
  background: #ffffff;
} */

.safety-table--two tr.tab-head {
  background: inherit!important;
}

.safety-table--two  tr.borderbtm0 .span4 {
  /* background: #F1F1F1 !important; */
  background: #FFF !important;
  border: none;
}

/*New style here - US-73966 */
.text.parbase ul.safety-list--first {
  margin-bottom: 20px;
}

.safety-table-callout {
  border: 1px solid #9B9B9B;
  max-width: 800px;
  width: 100%;
  padding: 10px 28px;
  font-weight: 600;
  margin-bottom: 58px;
}

.safety-table-callout > .subhead {
  margin-bottom: 10px!important;
}

.safety-table-callout .safet-table-callout__txt {
  font-weight: 600;
}

ul.safet-table-callout__list {
  margin-bottom: 0!important;
  padding-left: 10px;
  list-style-type: none!important;
}

ul.safet-table-callout__list > li::before {
  content: '\2022';
  position: absolute;
  left: -8px;
}

ul.safet-table-callout__list > li {
  position: relative;
  font-weight: 600;
}
/* Resectable safety page styling */

/* Metastatic safety page styling */

.metastatic-nsclc.safety .section-1 h1 {
  margin: 34px 0 43px 0;
}
/*.metastatic-nsclc.safety .section-1 .chart-head {*/
/*    max-width: 282px;*/
/*    margin: 0 auto;*/
/*}*/
table.customTable {
  margin: 20px auto 15px auto  !important;
  max-width: unset;
}

.metastatic-nsclc.safety .section-1 .subhead {
  margin: 35px 0 25px 0;
}
/*.metastatic-nsclc.safety .section-1 ul.bullet-list li{
  margin-bottom:15px;
}*/
ul.bullet-list.subsequentTreatment.mt30mob {
  margin-top: 30px;
}

.metastatic-nsclc.safety .section-1 .last-footnote {
  margin-bottom: 35px;
  text-indent: -10px;
  padding-left: 10px;
}

.metastatic-nsclc.safety .section-1 .chart-footnote {
  text-indent: 0;
  margin: 5px auto 35px;
  float: left;
  width: 100%;
  display: block;
  clear: both;
  overflow: hidden;
  padding-left: 37px;
}

.metastatic-nsclc.safety .section-2 h1 {
  margin: 55px 0 50px 0;
}

.metastatic-nsclc.safety .section-2 table.customTable {
  margin: 35px auto 70px!important;
}

.metastatic-nsclc.safety .section-3 .green-banner {
  margin: 30px 0 50px 0;
}

.metastatic-nsclc.safety .section-3 .green-banner p {
  padding: 4px 10px 4px 0;
}

.metastatic-nsclc.safety .section-4 .last-footnote {
  margin-bottom: 33px;
}

h2.first-line-tag {
  margin: 55px 0 50px 0;
  font-weight: 800;
  font-size: 30px;
  line-height: 36px;
  color: #5B305D;
}

.tagChemoSafety h2.first-line-tag {
  margin-bottom: 10px;
}

.tag-heading-txt {
  font-weight: 700 !important;
}

.dose-red {
  margin-top: -8px;
}

.safety-foot {
  margin-top: -5px;
}

h2.safety-adju {
  font-weight: 800;
  font-size: 30px;
  line-height: 36px;
  color: #5B305D;
}

.tagChemoSafety.metastatic-safety  ul.bullet-list.subsequentTreatment.mt30mob  ul.bullet-list.bullet-list-dash li:before {
  content: '\2013';
}

.tagChemoSafety #laboratory-abnormalities .customTable.lab-table tr th.chart-body.ffb-med.align{
        position: relative;
    left: 10px;
    }

/* Metastatic safety page styling ends */


@media screen and (max-width: 991px) {
.metastatic-nsclc.safety-side-effects .dose-reduction-list ul li li::marker{
  content:"" !important;
}
  .metastatic-nsclc.safety-side-effects .dose-reduction-list ul li li::before{
    content: "—" !important;
    display:block;
    left: -16px !important;
  }
  
    #table-footnote .page-section-inner

 {
    padding-top: 0;
}
    
  .tagChemoSafety .chemo-safety-median-2 .chart-label{
    font-size: 13px;
  }
  .new-number-box{
    display:none !important;
  }
  .new-number-box-mob {
    display: block !important;
  }
  .tagChemoSafety ul.bullet-list.dosingBulletList li ul li{
    margin-bottom: 15px;
  }
  #additional-results > div.page-section-inner.container > div:nth-child(5) > div > h1{
    margin-bottom: 85px !important;
  }
  .tagChemoSafety .chart-container.chemo-safety-median-1{
    margin-bottom: 60px !important;
  }
  .metastatic-safety--link a.primary-button, .primary-btn-wrap .primary-button{
    margin-bottom:40px;
  }
  .green-banner{
    margin: 3px auto 20px auto;
    /* width: 93%; */
  }
  .tagChemoSafety ul.bullet-list.dose-red.after-ar-table{
    margin-bottom: 10px;
    margin-top: 5px;
  }
  .eight-nine-graphic{
  position: absolute;
  width: 79px !important;
  height: 51px !important;
  }
  .dose-reduction-list .head-graphic{
    display: none !important;
  }
  .dose-reduction-list .head-graphic-mob .head-block{
  padding-left: 84px;
  display: block;
  }
    .dose-reduction-list .head-graphic-mob .subhead{
  position: relative;
  margin-top: 45px;
  margin-bottom: 15px;
  margin-right: -3px;
  }
  #additional-results > div.page-section-inner.container > div:nth-child(1) > div > p.tab-title.ffb-sb.head-wrap{
    padding: 0 20px;
  }
  .tagChemoSafety .ae-chart-wrapper img {
    margin-top: 15px;
  }

  .safety-side-effects .tables {
    flex-direction: column;
    align-items: center;
    margin-right: 0 !important;
    margin-left: 0 !important;
  }

  .safety-side-effects .tables > div {
    width: 100% !important;
  }

  .tagChemoSafety h2.first-line-tag {
    margin-top: 5px !important;
    margin-right: -8px;
  }

  .tagChemoSafety p.eyebrow.meta-safety-eyebrow-1.after-ae-table {
    padding-bottom: 15px;
  }

  #additional-results > div.page-section-inner.container > div:nth-child(2) > div > div {
    max-height: 1230px;
    overflow-y: hidden;
  }

  .bullet-list.dosingBulletList ul.bullet-list.bullet-list-dash li {
    padding: 0 26px 0 0;
  }

  ul.dosingBulletListBold li {
    padding: 0 34px 0 0;
  }

  .bullet-list.with-image .flex {
    display: flex;
    align-items: center;
    gap: 0;
    flex-direction: column;
  }

  .metastatic-nsclc.safety-side-effects .dose-reduction-list ul li li:before {
    content: '\2012';
    left: -11px;
    color: #333;
  }

  .metastatic-nsclc.safety-side-effects .dose-reduction-list ul {
    /* padding-left: 10px !important; */;
  }

  .metastatic-nsclc.safety-side-effects .dose-reduction-list ul li ul {
    list-style: none;
    padding-left: 20px;
  }
    
  /*footnotes */
  .resectable-nsclc.safety .safety-foot .footnotes {
    text-indent: -3px;
    padding-left: 0px;
     /* margin-left: 3px!important; */
    ;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(1) {
    margin-left: -4px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(2) {
    margin-left: -2px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(3) {
    margin-left: -3px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(4) {
    margin-left: -3px;
    text-indent: -3px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(5) {
          /* margin-left: -3px; */
    margin-left: -1px;
    text-indent: -3px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(6) {
    margin-left: -8px;
    text-indent: -5px;
    padding-left: 6px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(7) {
    margin-left: -8px;
    text-indent: -12px;
    padding-left: 7px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(8) {
    margin-left: -14px!important;
    text-indent: -4px;
    padding-left: 7px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(9) {
    margin-left: -10px;
    text-indent: -6px;
    padding-left: 7px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(10), .resectable-nsclc.safety .safety-foot .footnotes:nth-child(12) {
    margin-left: -7px!important;
    text-indent: -10px;
    padding-left: 7px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(11) {
    text-indent: -3px;
    padding-left: 2px;
      /* margin-left: 3px!important; */
    margin-left: -2px!important;
    text-indent: -9px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(13) {
    margin-left: -8px;
    text-indent: -10px;
    padding-left: 6px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(14) {
    margin-left: -9px;
    text-indent: -10px;
    padding-left: 5px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(15) {
    margin-left: -3px!important;
    text-indent: -11px;
      /* padding-left: 5px; */
    ;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(16) {
    margin-left: -8px!important;
  /* padding-left: 5px; */
    text-indent: -13px;
  /* margin-left: -10px!IMPORTANT; */
    padding-left: 7px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(17) {
    margin-left: -8px!important;
    text-indent: -13px;
    padding-left: 10px!important;
  }

  .metastatic-nsclc.safety .section-1 .footnotes {
    text-indent: -3px;
    padding-left: 3px;
     /* margin-left: 3px!important; */
    ;
  }

  .metastatic-nsclc.safety .section-1 .footnotes:nth-child(1) {
    margin-left: -6px;
  }

  .metastatic-nsclc.safety .section-1 .footnotes:nth-child(2) {
    margin-left: -4px;
  }

  .metastatic-nsclc.safety .section-1 .footnotes:nth-child(3) {
    margin-left: -5px;
  }

  .metastatic-nsclc.safety .section-1 .footnotes:nth-child(4) {
    margin-left: -4px;
    text-indent: -3px;
  }

  .metastatic-nsclc.safety .section-1 .footnotes:nth-child(5) {
          /* margin-left: -3px; */
    margin-left: -4px;
    text-indent: -3px;
  }

  .metastatic-nsclc.safety .section-1 .footnotes:nth-child(6) {
    margin-left: -7px;
    text-indent: -5px;
    padding-left: 6px;
  }

  .metastatic-nsclc.safety .section-1 .footnotes:nth-child(7) {
    margin-left: -5px;
    text-indent: -12px;
    padding-left: 10px;
  }

  .metastatic-nsclc.safety .section-1 .footnotes:nth-child(8) {
    margin-left: -11px!important;
    text-indent: -4px;
    padding-left: 4px;
  }

  .metastatic-nsclc.safety .section-1 .footnotes:nth-child(9) {
    margin-left: -7px;
    text-indent: -7px;
    padding-left: 5px;
  }

  .metastatic-nsclc.safety .section-1 .footnotes:nth-child(10), .metastatic-nsclc.safety .section-1 .footnotes:nth-child(12) {
    margin-left: -7px!important;
    text-indent: -10px;
    padding-left: 7px;
  }

  .metastatic-nsclc.safety .section-1 .footnotes:nth-child(11) {
    text-indent: -3px;
    padding-left: 2px;
      /* margin-left: 3px!important; */
    margin-left: -2px!important;
    text-indent: -9px;
  }

  .metastatic-nsclc.safety .section-1 .footnotes:nth-child(13) {
    margin-left: -8px;
    text-indent: -10px;
    padding-left: 6px;
  }

  .metastatic-nsclc.safety .section-1 .footnotes:nth-child(14) {
    margin-left: -9px;
    text-indent: -10px;
    padding-left: 5px;
  }

  .metastatic-nsclc.safety .section-1 .footnotes:nth-child(15) {
    margin-left: -3px!important;
    text-indent: -11px;
      /* padding-left: 5px; */
    ;
  }

  .metastatic-nsclc.safety .section-1t .footnotes:nth-child(16) {
    margin-left: -8px!important;
      /* padding-left: 5px; */
    text-indent: -11px;
      /* margin-left: -10px!IMPORTANT; */
    padding-left: 7px;
  }

  .metastatic-nsclc.safety .section-1 .footnotes:nth-child(17) {
    margin-left: -8px!important;
    text-indent: -13px;
    padding-left: 7px;
  }

  .metastatic-nsclc.safety .section-3 .green-banner p {
    padding: 1px 10px 4px 0;
  }

  .resectable-nsclc.safety .section-1 h1 {
    margin: 34px 10px 25px 0;
  }

  .resectable-nsclc.safety .section-1 .subhead {
    margin: 0 3px 35px 0;
  }

  .safety-table-callout {
    padding: 10px 15px;
  }

  .customTable th, .customTable td {
    font-size: 15px;
    line-height: 24px !important;
    letter-spacing: -0.38px;
    padding: 7px !important;
  }

  .second-table td.chart-body-copy.ffb-sb.purple-txt {
    line-height: 20px !important;
  }

  .safety-table-update {
    padding-top: 30px !important;
    padding-bottom: 5px !important;
  }

  .customTable th {
    line-height: 17px !important;
    padding: 0 2px 5px 2px !important;
  }

  .section-1 .gradethree-text {
    padding-top: 12px;
  }

  .section-2 .gradethree-text {
    padding-top: 27px;
  }

  th.tag-purple-color.ffb-med.heading-text {
    line-height: 17px !important;
    padding-bottom: 13px !important;
  }

  .section-1 th.tag-purple-color.ffb-med.heading-text {
    padding-bottom: 7px !important;
  }

  .tag-purple-color,.tag-grey-color {
    line-height: 17px !important;
  }

  .customTable .charthead3 {
    line-height: 19px !important;
    letter-spacing: -0.32px;
  }

  .resectable-nsclc.safety .section-1 .bullet-list li {
    margin: 20px 0 10px 0;
  }

  .resectable-nsclc.safety .section-1 .chart-footer {
    text-indent: 0;
    margin: 0 0 30px 0;
  }

  .resectable-nsclc.safety .section-1 .subhead2 {
    margin: 60px 0 30px 0;
  }

  .resectable-nsclc.safety .section-1 ul li:nth-child(2) {
    margin: 15px 0 35px 0;
  }

  .resectable-nsclc.safety .section-1 .last-footnote {
    margin: 0 0 35px 0;
  }

  .resectable-nsclc.safety .section-2 h2 {
    margin: 55px 0 40px 0;
  }

  .resectable-nsclc.safety .section-2 .chart-below-copy {
    margin: 40px 0 35px -1px;
  }

  .resectable-nsclc.safety .section-2 .chart-heading {
    font-size: 15px;
  }

  .metastatic-nsclc.safety .section-1 h1 {
    margin: 34px 0 40px 0;
  }

  .metastatic-nsclc.safety  .span4 {
    border-bottom: 1px solid transparent !important;
    font-weight: 600 !important;
  }

  th.chart-head3 {
    font-size: 17px;
    line-height: 19px !important;
    padding: 55px 0 8px 6px;
    font-weight: 700 !important;
  }

  .metastatic-nsclc.safety .section-1 .chart-footnote {
    margin: 0 auto 38px;
    padding-left: 0;
  }

  .metastatic-nsclc.safety .section-1 .subhead {
    margin: 35px 0 25px 0;
  }

/*.metastatic-nsclc.safety .section-1 ul.bullet-list {
  margin-bottom: 30px !important;
}*/

  .metastatic-nsclc.safety .section-1 ul.bullet-list li {
    letter-spacing: -0.24px;
  /*margin-bottom: 10px;*/
    ;
  }

  ul.bullet-list.mb-20mob {
    margin-top: -40px !important;
  }

  .metastatic-nsclc.safety .section-1 .last-footnote {
    margin-bottom: 35px;
  }

  .metastatic-nsclc.safety .section-2 h1 {
    margin: 55px 0 50px 0;
  }

  .metastatic-nsclc.safety .text-left {
    margin-left: 0px!important;
    text-indent: 0!important;
  }

  .metastatic-nsclc.safety .section-2 .span4 {
    border-bottom: 1px solid transparent !important;
  }

  .metastatic-nsclc.safety .section-2 table.customTable {
    margin: 15px auto 30px!important;
  }

  .metastatic-nsclc.safety .section-3 .green-banner {
    margin: 20px 0 28px 0;
    width: 89%;
    padding: 11px 0px 11px 38px;
  }

  .metastatic-nsclc.safety .section-4 .last-footnote {
    margin-bottom: 35px;
  }

  .erlo-gefi,.gefitinib,.ffb-med-n {
    display: block;
  }

  .resectable-nsclc.safety .section-1 .bullet-list li {
    margin-top: 0;
    margin-bottom: 0;
  }

  .resectable-nsclc.safety .section-1 ul li:nth-child(2) {
    margin-top: 0;
    margin-bottom: 0;
  }

  .customTable tr:nth-child(1) th {
    padding-bottom: 7px !important;
  }
#adverse-reactions > div.page-section-inner.container > div:nth-child(2) > div > div > div.first-table > table > tbody > tr:nth-child(1) > th:nth-child(3){
  padding: 0 6px 7px 6px !important;
}
    /*****81422*****/
  .tagChemoSafety .chemo-safety-median-1 .chart-bar::after {
    right: -12.7px;
    border-top: 33.5px solid transparent;
    border-left: 13px solid #5B305D;
    border-bottom: 33.3px solid transparent;
  }

  .tagChemoSafety .chemo-safety-median-2 .chart-bar-tagrisso::after {
    right: -13.1px;
    border-top: 33.5px solid transparent;
    border-left: 13px solid #5B305D;
    border-bottom: 33.3px solid transparent;
  }

  .tagChemoSafety .chemo-safety-median-2 .chart-bar.subtle-color::after {
    right: -12.5px;
  }

  .tagChemoSafety .dose-reduction-list h2.first-line-tag {
    margin-top: 0px;
  }

      /*****81422*****/;
}

p.footnotes.triple-footnotes.last-footnote.extra-footnote.-two {
/*padding-left: 1px;*/
  padding-left: 5px;
  margin-left: -13px!important;
}

p.footnotes.triple-footnotes.extrafootnote-one {
  padding-left: 3px;
/*text-indent: -16px;*/
  text-indent: -3px;
}

@media screen and (min-width: 320px) and (max-width: 370px) {
  .metastatic-nsclc.safety .section-3 .green-banner {
    width: 88%;
  }

  .customTable th, .customTable td {
    padding: 0;
    font-size: 13px;
  }
  
  
  /**/
  
}

.tagChemoSafety .subsequentTreatment ul.bullet-list-dash li,.tagChemoSafety .dosingBulletList ul.bullet-list-dash li {
  margin-left: 7px;
  padding-bottom: 0;
}

.tagChemoSafety .subsequentTreatment ul.bullet-list-dash li:before,.tagChemoSafety .dosingBulletList ul.bullet-list-dash li:before {
  content: '\2014';
  left: -15px;
}
  #adverse-reactions > div.page-section-inner.container > div:nth-child(3) > div > ul > li:nth-child(2) > ul > li{
    padding-top:0
  }
@media screen and (min-width:992px) {
  #adverse-reactions > div.page-section-inner.container > div:nth-child(2) > div > div{
  margin-bottom:34px
}
    .metastatic-nsclc.safety-side-effects .dose-reduction-list ul li li::marker{
    content: "— " !important;
  }
#additional-results > div.page-section-inner.container > div:nth-child(4) > div > p:nth-child(1){
  padding-right:40px
}
  .before-isi {
   margin-bottom: 30px;
  }
  #additional-results > div.page-section-inner.container > div:nth-child(5) > div > h1{
    margin-bottom: 10px !important;
  }
  #adverse-reactions > div.page-section-inner.container > div:nth-child(1) > div > h1{
      padding-right: 72px;
  }
  #additional-results > div.page-section-inner.container > div:nth-child(1) > div > p.tab-title.ffb-sb.head-wrap{
    margin: 25px 0 20px 0;
  }
  .green-banner{
    margin: 0px 0 34px;
  }
   .green-banner .banner-content{
  padding-right: 40px;
  }
    .second-table{
      margin-bottom: 35px;
    }
    /*****81422*****/
  .tagChemoSafety .chart-duration.chart-duration-tagrisso {
    line-height: 16px!important;
  }

  .tagChemoSafety .chemo-safety-median-2 .chart-bar.chart-bar-platinum.subtle-color .chart-label {
    line-height: 11px;
  }

  .tagChemoSafety ul.bullet-list.dosingBulletList li ul li {
    margin-bottom: 15px;
  }

  .metastatic-nsclc.safety-side-effects .dose-reduction-list ul li li:before {
    content: '\2014';
    left: -15px;
    color: #333;
  }

  .metastatic-nsclc.safety-side-effects .dose-reduction-list ul li li {
    /* list-style: none; */
    margin-top: 0px;
  }

  .tagChemoSafety .chemo-safety-median-1 .chart-bar::after {
    right: -8px;
  }

  .tagChemoSafety .chemo-safety-median-2 .chart-duration.chart-duration-platinum {
    line-height: 16px;
  }

  .metastatic-nsclc.safety .section-1 h1.meta-safety-head-1 {
    margin-bottom: 15px!important;
  }

  .tagChemoSafety .dose-reduction-list h2.first-line-tag {
    margin-bottom: 35px;
    margin-top: 35px;
  }

  .tagChemoSafety .dose-reduction-list ul ul {
    padding-left: 15px;
  }

  .tagChemoSafety p.eyebrow.after-manage-cta {
    padding-top: 66px;
    padding-bottom: 15px;
  }

  .tagChemoSafety p.eyebrow.meta-safety-eyebrow-1.after-ae-table {
    padding: 55px 0 15px 0;
  }

  .tagChemoSafety .dose-reduction-list ul li {
    margin-top: 10px;
  }

  .tagChemoSafety .metastatic-safety--link a.primary-button {
    margin: 40px auto 50px auto;
  }





/*****81422*****/
    
    
    
    
/*   .resectable-nsclc.safety .footnotes{*/
/*    padding-left:0px;*/
/*}*/
/*.resectable-nsclc.safety .double-footnotes{*/
/*        text-indent: 0px;*/
/*        padding-left:0px;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes{*/
/*    text-indent: -3px;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes:nth-child(3){*/
/*        margin-left: -2px;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes:nth-child(4){*/
/*        margin-left: -1px;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes:nth-child(6){*/
/*        text-indent: -4px;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes:nth-child(7){*/
/*        margin-left: 1px!important;*/
/*    text-indent: -12px!important;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes:nth-child(8){*/
/*        margin-left: -10px;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes:nth-child(9){*/
/*        margin-left: -3px;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes:nth-child(10){*/
         /* margin-left: -2px; */
/*    text-indent: -6px;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes:nth-child(10){*/
         /* margin-left: -2px; */
/*           margin-left: -4px;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes:nth-child(11){*/
         /* margin-left: -2px; */
/*           margin-left: -3px;*/
/*           text-indent: -7px;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes:nth-child(12){*/
         /* margin-left: -2px; */
/*           margin-left: -4px;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes:nth-child(13){*/
         /* margin-left: -2px; */
/*           margin-left: -6px;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes:nth-child(14){*/
         /* margin-left: -2px; */
/*           margin-left: -7px;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes:nth-child(15){*/
         /* margin-left: -2px; */
/*                   margin-left: -10px;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes:nth-child(16), .resectable-nsclc.safety .safety-foot .last-footnote{*/
         /* margin-left: -2px; */
/*           margin-left: -8px!important;*/
/*}*/
/*.resectable-nsclc.safety .safety-foot .footnotes:nth-child(17){*/
         /* margin-left: -2px; */
/*                          margin-left: -6px;*/
/*}*/
  .resectable-nsclc.safety .footnotes {
    padding-left: 0px;
  }

  .resectable-nsclc.safety .double-footnotes {
    text-indent: 0px;
    padding-left: 0px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes {
    text-indent: -3px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(1) {
    margin-left: -1px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(3) {
    margin-left: -2px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(4) {
    margin-left: -1px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(6) {
    text-indent: -5px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(7) {
    margin-left: 1px!important;
    text-indent: -12px!important;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(8) {
    margin-left: -6px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(9) {
    margin-left: -4px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(10) {
         /* margin-left: -2px; */
    text-indent: -6px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(10) {
         /* margin-left: -2px; */
    margin-left: -3px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(11) {
           /* margin-left: -2px; */
    margin-left: 0px;
    text-indent: -8px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(12) {
         /* margin-left: -2px; */
    margin-left: -5px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(13) {
         /* margin-left: -2px; */
    margin-left: -6px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(14) {
         /* margin-left: -2px; */
    margin-left: -8px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(15) {
         /* margin-left: -2px; */
    margin-left: -10px;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(16), .resectable-nsclc.safety .safety-foot .last-footnote {
         /* margin-left: -2px; */
    margin-left: -8px!important;
  }

  .resectable-nsclc.safety .safety-foot .footnotes:nth-child(17) {
         /* margin-left: -2px; */
    margin-left: -6px;
  }
/* existing*/
  .resectable-safety .section-1 .single-footnotes {
/*text-indent: -7px;*/
    text-indent: -5px;
  }

  .resectable-safety .section-1 .double-footnotes {
  /*text-indent: -9px;*/
    text-indent: 0px;
    padding-left: 0;
  }

  .resectable-safety .section-1 .triple-footnotes {
/*text-indent: -16px;*/
    text-indent: -5px;
  }

  .resectable-safety .section-1 .ten-footnotes {
/*text-indent: -10px;*/
    text-indent: -5px;
  }

  .resectable-safety .section-1 .eleven-footnotes {
  /* text-indent: -11px; */
    text-indent: -8px;
    margin-left: 0px;
  }

  .resectable-safety .section-1 .twel-footnotes {
/*text-indent: -12px;*/
    text-indent: -5px;
  }

  .resectable-safety .section-1 .seventeen-footnotes {
/*text-indent: -13px;*/
    text-indent: -5px;
  } 

/*meta static*/
  .metastatic-safety .section-1 .double-footnotes {
    text-indent: 0px;
    padding-left: 0px;
  }
/*.metastatic-safety .section-1 .footnotes{
  text-indent: -3px;
  padding-left:0px;
}
.metastatic-safety .section-1 .footnotes:nth-child(3){
      margin-left: -2px;
}
.metastatic-safety .section-1 .footnotes:nth-child(4),
.metastatic-safety .section-1 .footnotes:nth-child(5),
.metastatic-safety .section-1 .footnotes:nth-child(1),
.metastatic-safety .section-1 .footnotes:nth-child(2){
      //margin-left: -1px!important;
      margin-left: 5px !important;
}
.metastatic-safety .section-1 .footnotes:nth-child(6){
      text-indent: -5px;
      margin-left: -1px;
}
.metastatic-safety .section-1 .footnotes:nth-child(7){
      margin-left: 0px!important;
      text-indent: -7px!important;
}
.metastatic-safety .section-1 .footnotes:nth-child(8){
      margin-left: -7px;
}
.metastatic-safety .section-1 .footnotes:nth-child(9){
      margin-left: -6px;
}
.metastatic-safety .section-1 .footnotes:nth-child(10){
         //margin-left: -2px; 
  text-indent: -6px;
}
.metastatic-safety .section-1 .footnotes:nth-child(10){
         // margin-left: -2px;
         margin-left: -3px;
}
.metastatic-safety .section-1 .footnotes:nth-child(11){
         //* margin-left: -2px; 
         margin-left: -9px!important;
         text-indent: -9px;
}
.metastatic-safety .section-1 .footnotes:nth-child(12){
         //* margin-left: -2px; 
         margin-left: -4px;
}
.metastatic-safety .section-1 .footnotes:nth-child(13){
         //* margin-left: -2px; 
         margin-left: -6px;
}
.metastatic-safety .section-1 .footnotes:nth-child(14){
         //* margin-left: -2px; 
         margin-left: -7px;
}
.metastatic-safety .section-1 .footnotes:nth-child(15){
         //* margin-left: -2px; 
                 margin-left: -10px;
}
.metastatic-safety .section-1 .footnotes:nth-child(16), .metastatic-safety .section-1 .last-footnote{
         //* margin-left: -2px; 
         margin-left: -8px!important;
}

.metastatic-safety .section-1 .footnotes:nth-child(17){
         //* margin-left: -2px; 
                        margin-left: -6px;
}*/;
}
/*.metastatic-nsclc.safety .section-1 .footnotes:nth-child(9),.metastatic-nsclc.safety .section-1 .footnotes:nth-child(10),
.metastatic-nsclc.safety .section-1 .footnotes:nth-child(8),.metastatic-nsclc.safety .section-1 .footnotes:nth-child(11) {
  text-indent: -12px;
}*/


.safety-side-effects .tables {
    /* margin-left: -20%; */
    /* margin-right: -20%; */
    gap: 20px;
    flex-direction: column;
    margin: 0 auto;
    max-width: 750px;
    display: flex;
}

.safety-side-effects .tables > div {
  /* width:50%; */;
}

.safety-side-effects .tables .second-table .customTable td:nth-child(1) {
  width: 55%;
}

.safety-side-effects .tables .second-table .customTable td:nth-child(1) >div p {
  font-size: 16px;
  font-weight: 500;
  line-height: 18px !important;
  height: fit-content;
  color: #333333;
  margin: 0;
}

.safety-side-effects .tables .second-table .customTable td:nth-child(1)>div {
  align-items: center;
  display: flex;
}

.safety-side-effects .tables .tab-title {
  font-size: 15px;
  line-height: 1.2 !important;
}

.safety-side-effects .tables .second-table > p {
  /* margin-bottom: 41px; */;
}

.safety-side-effects .tables .first-table .customTable td {
  line-height: 30px;
}

.safety-side-effects .tables .second-table .customTable td {
  line-height: 20px;
  padding: 11px 12px !important;
}

.safety-side-effects .polygon {
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/global/nccn-chevron-desktop-1.png) no-repeat;
  background-size: 100% 100%;
  height: unset;
  width: fit-content;
  padding: 10px 8px;
  margin-right: 8px;
}

.safety-side-effects .tables .second-table .customTable td:nth-child(1) .polygon p {
  color: white;
  font-size: 23px;
  margin: 0;
  padding-right: 3px;
  line-height: 1 !important;
}

.safety-side-effects .tables .first-table table > tbody > tr:nth-child(2) > th {
  padding: 4px 4px;
  border: none;
}

.safety-side-effects .tables .first-table table > tbody > tr:nth-child(2) > th:not(:first-child) {
  width: 60px;
}

#adverse-reactions > div.page-section-inner.container > div:nth-child(2) > div > div > div.second-table > table > tbody > tr:nth-child(1) > th.chart-head3.text-left {
  padding-top: 32px;
}

.safety-side-effects.metastatic-nsclc  .tables .second-table p.subtext-cel {
  font-size: 12px !important;
  letter-spacing: -0.2px;
  margin-top: 3px !important;
}

.safety-side-effects .tables .second-table .customTable td:nth-child(1) >div p.subtext-cel {
  line-height: 13px !important;
}

.safety-side-effects .customTable th {
  line-height: 19px !important;
  vertical-align: bottom;
}
.tagChemoSafety .dose-reduction-list ul li{
    position: relative;
}
.tagChemoSafety .dose-reduction-list ul li:before {
  content: '\2022';
  color: #009398;
  position: absolute;
  left: -9px;
  font-size: 16px;
  top: auto;
}


/*.safety-side-effects .dose-reduction-list ul.bullet-list{*/
/*    margin-left: 0px !important;*/
/*}*/


@media (min-width: 992px) {
   .tagChemoSafety .chemo-safety-median-2 .chart-title{
   left:50%;
   transform:translate(-50%,0);
   width: fit-content;
   padding: 0px 8px;
 }
  .tagChemoSafety .chemo-safety-median-2.chart-container::before{
    /* left: 50%; */
    /* transform: translate(-50%,0); */
    opacity: 0;
  }
  .tagChemoSafety .chemo-safety-median-1 .chart-title{
      left:50%;
      transform:translate(-50%,0);
      width: fit-content;
      padding: 0px 8px;
  }
  .tagChemoSafety .chemo-safety-median-1.chart-container::before{
        opacity: 0;

  }
.head-graphic-mob{
  display:none;
}
    .safety-side-effects #laboratory-abnormalities .lab-table{
    margin: 20px auto 25px auto !important;
    max-width: 750px;
    }
     .safety-side-effects .dose-reduction-list ul.bullet-list{
        padding-right: 30px;
        margin-left: 25px !important;
    }
}


.eight-nine-graphic{
  content: "";
  display: block;
  background: url(/content/dam/open-digital/tagrisso-hcp/us/en/chemotherapy/desktop/89graphic.png) no-repeat;
  height: 74px;
  background-size: cover;
  width: 113px;
  /* flex: 1; */
}

.dose-reduction-list .head-graphic{
  display: flex;
  align-items:center;
  gap: 7px;
  margin-top: 40px;
  margin-bottom: 10px;
}
.dose-reduction-list .head-graphic .subhead{
  flex:1;
  margin: 0;
}
.dose-reduction-list ul li:before{
  display:none;
}
.no-wrap{
  white-space:nowrap
}
.new-number-box{
  display: flex;
  color: #333333;
  align-items: center;
}

.new-number-box .chart-months-number{
  font-size: 34px;
  font-weight: bold;
  padding: 0 5px 2px 2px;
}
div.new-number-box > div:nth-child(2){
  display:flex;
  line-height: normal;
  line-height: 16px;
  flex-direction:column;
  padding-bottom: 2px;
}
div.new-number-box > div:nth-child(2) > span:nth-child(1){
  font-size: 15px;
  /* font-weight: bold; */
  /* color: #4a235a; */
}

.chart-row.pemetrexed{
  padding-top: 6px;
}
.chart-row.chart-bar-platinum{
  padding-top: 6px;
  margin-bottom: 25px !important;
}
.primary-text-color{
    color: #5B305D !important;
}

.new-number-box-mob {
  display:none;
  padding-left: 5px;
  font-size: 11px;
  color: #333332;
  line-height: 14px;
  margin-right: -6px;
}
.new-number-box-mob .big-number {
  font-size: 21px;
  font-weight:bold;
}
.chemo-safety-median-1 div.new-number-box-mob.primary-text-color{
  max-width: 84px;
}
#additional-results > div.page-section-inner.container > div:nth-child(6) > div > div > img.mobile-only{
  position:relative;
  /* right:4px; */
  max-width: 100%;
}
  .metastatic-nsclc.safety-side-effects .dose-reduction-list ul li li::marker{
    content: "—  ";
  }


.safety-side-effects .eyebrow a {
    font-size: 22px;
    text-decoration: underline;
    line-height: 26px;
    font-weight: 500;
    color: #5B305D;
    padding-bottom: 10px;
}
.tagChemoSafety p.eyebrow.meta-safety-eyebrow-1 {
    margin : 3px 0px 5px;
}




/*Fixing nav bar issue */

@media screen and (max-width : 1200px){
     .top-header .navbar-header .logo img {
    max-width : 200px
    }
   .vertical-list-dropdown .list-dropdown.dropdown-menu li{
     max-width : 300px
    }
 .top-header-links .top-nav ul{
  max-width : 480px;
  position :absolute;
  right : 5px;
  top: -3px
 }
 .therapyToggleWrap{
  max-width : 350px
 }
}
@media screen and (max-width : 1160px){
     .top-header .navbar-header .logo img {
    max-width : 180px
    }
  .vertical-list-dropdown .list-dropdown.dropdown-menu li{
     max-width : 300px
    }
 
 .top-header-links .top-nav ul{
  max-width : 480px;
  position :absolute;
  right : 5px;
  top: -3px
 }
 .therapyToggleWrap{
  max-width : 250px;
 }
}

@media screen and (max-width : 1110px){
  .top-header .navbar-header .logo img {
    max-width : 170px
    }
  .vertical-list-dropdown .list-dropdown.dropdown-menu li{
     max-width : 230px
    }
  .therapyToggleWrap{
  max-width : 235px;
   box-sizing : border-box; 
   padding : 6px 4px
 }
}


@media screen and (max-width : 1120px){
.top-header-links .top-nav ul { 
 max-width : 460px
}
}

@media screen and (max-width : 1080px){
.top-header-links .top-nav ul { 
 max-width : 350px
}
}
@media screen and (max-width : 765px){
    .dose-red-sub-list{
        max-width : 680px
    }
}



@media screen and (max-width : 375px){
    .second-table table{
   margin : 0px -11px !important
}
    .no-wrap{
        white-space :normal
    }
    .component-section .bg-white{
        overflow : hidden; 
        overflow-x : clip;
    }
    
.tagChemoSafety #laboratory-abnormalities .customTable.lab-table tr th.chart-body.ffb-med.align{
	left: 0px;
}
 table.mb-lft{
   margin: 0 -1px !important;
 }
.customTable th{
    padding : 0 0px 5px 2px !important
}
    
}

@media screen and (min-width:320px) and (max-width:375px){
  .metastatic-safety--link a.primary-button, .primary-btn-wrap .primary-button{
    line-height: 19px !important;
    padding: 9px 20px 0 0px;
  }
}


.section-heading-mobile{
    text-transform:capitalize;
}


.as-up{
  position:relative;
  top: -3.0px;
}
.tagChemoSafety .cm-adv

 {
    position: relative;
    left: 7px;
}